SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ka0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_C_CHDC150_0 (ILEAL BILE ACID-BINDING PROTEIN)	2ka0	UNCHARACTERIZED PROTEIN TM1367 (Thermotoga maritima)	5 / 12	THR A 47 VAL A 49 PHE A 45 VAL A 13 ILE A 14	None	1.23A	3elzC-2ka0A: undetectable	3elzC-2ka0A: 25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_D_CHDD102_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	2ka0	UNCHARACTERIZED PROTEIN TM1367 (Thermotoga maritima)	5 / 11	LEU A 5 GLU A 42 LEU A 77 ALA A 74 LEU A 75	None	1.09A	4wg0D-2ka0A: undetectable 4wg0E-2ka0A: undetectable 4wg0F-2ka0A: undetectable	4wg0D-2ka0A: 8.77 4wg0E-2ka0A: 8.77 4wg0F-2ka0A: 8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_J_CHDJ103_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	2ka0	UNCHARACTERIZED PROTEIN TM1367 (Thermotoga maritima)	5 / 11	LEU A 5 GLU A 42 LEU A 77 ALA A 74 LEU A 75	None	1.04A	4wg0J-2ka0A: undetectable 4wg0K-2ka0A: undetectable 4wg0L-2ka0A: undetectable	4wg0J-2ka0A: 8.77 4wg0K-2ka0A: 8.77 4wg0L-2ka0A: 8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_K_CHDK103_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	2ka0	UNCHARACTERIZED PROTEIN TM1367 (Thermotoga maritima)	5 / 11	ALA A 74 LEU A 75 GLU A 42 LEU A 77 LEU A 5	None	1.01A	4wg0I-2ka0A: undetectable 4wg0J-2ka0A: undetectable 4wg0K-2ka0A: undetectable	4wg0I-2ka0A: 8.77 4wg0J-2ka0A: 8.77 4wg0K-2ka0A: 8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WQ4_A_ACTA403_0 (TRNA N6-ADENOSINE THREONYLCARBAMOYLTRA NSFERASE)	2ka0	UNCHARACTERIZED PROTEIN TM1367 (Thermotoga maritima)	3 / 3	VAL A 22 LEU A 26 VAL A 49	None	0.43A	4wq4A-2ka0A: undetectable	4wq4A-2ka0A: 19.14

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3ELZ_C_CHDC150_0","ILEAL BILE ACID-BINDING PROTEIN","2ka0","UNCHARACTERIZED PROTEIN TM1367","Thermotoga maritima",5,"THR A  47;VAL A  49;PHE A  45;VAL A  13;ILE A  14","None","1.23A","3elzC-2ka0A:undetectable","3elzC-2ka0A:25.18"],["4WG0_D_CHDD102_0","NUCLEAR RECEPTOR COACTIVATOR 2","2ka0","UNCHARACTERIZED PROTEIN TM1367","Thermotoga maritima",5,"LEU A   5;GLU A  42;LEU A  77;ALA A  74;LEU A  75","None","1.09A","4wg0D-2ka0A:undetectable;4wg0E-2ka0A:undetectable;4wg0F-2ka0A:undetectable","4wg0D-2ka0A:8.77;4wg0E-2ka0A:8.77;4wg0F-2ka0A:8.77"],["4WG0_J_CHDJ103_0","NUCLEAR RECEPTOR COACTIVATOR 2","2ka0","UNCHARACTERIZED PROTEIN TM1367","Thermotoga maritima",5,"LEU A   5;GLU A  42;LEU A  77;ALA A  74;LEU A  75","None","1.04A","4wg0J-2ka0A:undetectable;4wg0K-2ka0A:undetectable;4wg0L-2ka0A:undetectable","4wg0J-2ka0A:8.77;4wg0K-2ka0A:8.77;4wg0L-2ka0A:8.77"],["4WG0_K_CHDK103_0","NUCLEAR RECEPTOR COACTIVATOR 2","2ka0","UNCHARACTERIZED PROTEIN TM1367","Thermotoga maritima",5,"ALA A  74;LEU A  75;GLU A  42;LEU A  77;LEU A   5","None","1.01A","4wg0I-2ka0A:undetectable;4wg0J-2ka0A:undetectable;4wg0K-2ka0A:undetectable","4wg0I-2ka0A:8.77;4wg0J-2ka0A:8.77;4wg0K-2ka0A:8.77"],["4WQ4_A_ACTA403_0","TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE","2ka0","UNCHARACTERIZED PROTEIN TM1367","Thermotoga maritima",3,"VAL A  22;LEU A  26;VAL A  49","None","0.43A","4wq4A-2ka0A:undetectable","4wq4A-2ka0A:19.14"]]