SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ka9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_ACTA504_0 (CHORISMATE SYNTHASE)	2ka9	DISKS LARGE HOMOLOG 4 (Rattus norvegicus)	4 / 5	SER A 33 ARG A 91 LEU A 58 SER A 56	None	1.38A	2qhfA-2ka9A: 0.0	2qhfA-2ka9A: 22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NXU_B_RITB600_2 (CYTOCHROME P450 3A4)	2ka9	DISKS LARGE HOMOLOG 4 (Rattus norvegicus)	5 / 9	ARG A 85 ILE A 6 LEU A 15 GLU A 62 GLY A 81	None	1.35A	3nxuB-2ka9A: undetectable	3nxuB-2ka9A: 16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AN2_A_EUIA1382_2 (DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1)	2ka9	DISKS LARGE HOMOLOG 4 (Rattus norvegicus)	4 / 4	ASN A 156 SER A 128 LEU A 153 THR A 175	None	1.32A	4an2A-2ka9A: undetectable	4an2A-2ka9A: 24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KBW_A_RBFA201_1 (RIBOFLAVIN TRANSPORTER RIBU)	2ka9	DISKS LARGE HOMOLOG 4 (Rattus norvegicus)	5 / 12	GLU A 79 LEU A 77 LYS A 78 ASN A 61 LEU A 86	None	1.29A	5kbwA-2ka9A: undetectable	5kbwA-2ka9A: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TZO_B_7V7B201_1 (ENDO-1,4-BETA-XYLANA SE A)	2ka9	DISKS LARGE HOMOLOG 4 (Rattus norvegicus)	5 / 12	LEU A 86 SER A 82 VAL A 84 ALA A 80 GLY A 81	None	1.17A	5tzoB-2ka9A: undetectable	5tzoB-2ka9A: 20.37

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2QHF_A_ACTA504_0","CHORISMATE SYNTHASE","2ka9","DISKS LARGE HOMOLOG 4","Rattus norvegicus",4,"SER A  33;ARG A  91;LEU A  58;SER A  56","None","1.38A","2qhfA-2ka9A:0.0","2qhfA-2ka9A:22.33"],["3NXU_B_RITB600_2","CYTOCHROME P450 3A4","2ka9","DISKS LARGE HOMOLOG 4","Rattus norvegicus",5,"ARG A  85;ILE A   6;LEU A  15;GLU A  62;GLY A  81","None","1.35A","3nxuB-2ka9A:undetectable","3nxuB-2ka9A:16.26"],["4AN2_A_EUIA1382_2","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","2ka9","DISKS LARGE HOMOLOG 4","Rattus norvegicus",4,"ASN A 156;SER A 128;LEU A 153;THR A 175","None","1.32A","4an2A-2ka9A:undetectable","4an2A-2ka9A:24.44"],["5KBW_A_RBFA201_1","RIBOFLAVIN TRANSPORTER RIBU","2ka9","DISKS LARGE HOMOLOG 4","Rattus norvegicus",5,"GLU A  79;LEU A  77;LYS A  78;ASN A  61;LEU A  86","None","1.29A","5kbwA-2ka9A:undetectable","5kbwA-2ka9A:24.14"],["5TZO_B_7V7B201_1","ENDO-1,4-BETA-XYLANASE A","2ka9","DISKS LARGE HOMOLOG 4","Rattus norvegicus",5,"LEU A  86;SER A  82;VAL A  84;ALA A  80;GLY A  81","None","1.17A","5tzoB-2ka9A:undetectable","5tzoB-2ka9A:20.37"]]