SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kb2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 2kb2 BLRP1
(Klebsiella
pneumoniae) 		4 / 6 LEU A  43
ASP A  99
LEU A  80
HIS A  74
 FMN  A 149 ( 4.3A)
None
None
FMN  A 149 ( 3.6A)
 1.14A 1errB-2kb2A:
undetectable		 1errB-2kb2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 2kb2 BLRP1
(Klebsiella
pneumoniae) 		6 / 12 THR A 105
ALA A 108
GLU A 111
LEU A  98
LEU A 102
GLY A  47
 None
 1.42A 1qknA-2kb2A:
undetectable		 1qknA-2kb2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 2kb2 BLRP1
(Klebsiella
pneumoniae) 		3 / 3 GLN A  52
ILE A   9
TYR A  10
 FMN  A 149 ( 3.4A)
None
None
 0.56A 1vifA-2kb2A:
undetectable		 1vifA-2kb2A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2kb2 BLRP1
(Klebsiella
pneumoniae) 		4 / 5 LEU A  43
ASP A  99
LEU A  80
HIS A  74
 FMN  A 149 ( 4.3A)
None
None
FMN  A 149 ( 3.6A)
 1.16A 2jfaA-2kb2A:
undetectable		 2jfaA-2kb2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 2kb2 BLRP1
(Klebsiella
pneumoniae) 		4 / 5 LEU A  43
ASP A  99
LEU A  80
HIS A  74
 FMN  A 149 ( 4.3A)
None
None
FMN  A 149 ( 3.6A)
 1.13A 2qxsA-2kb2A:
undetectable		 2qxsA-2kb2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 2kb2 BLRP1
(Klebsiella
pneumoniae) 		4 / 5 LEU A  43
ASP A  99
LEU A  80
HIS A  74
 FMN  A 149 ( 4.3A)
None
None
FMN  A 149 ( 3.6A)
 1.13A 2qxsB-2kb2A:
undetectable		 2qxsB-2kb2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2kb2 BLRP1
(Klebsiella
pneumoniae) 		4 / 5 GLN A  49
PHE A  50
LEU A  98
PHE A 103
 None
FMN  A 149 ( 3.1A)
None
None
 1.31A 3ablC-2kb2A:
undetectable
3ablJ-2kb2A:
undetectable		 3ablC-2kb2A:
20.31
3ablJ-2kb2A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2kb2 BLRP1
(Klebsiella
pneumoniae) 		3 / 3 ASN A  46
LEU A  26
PHE A  51
 None
FMN  A 149 (-4.0A)
None
 0.58A 4dajB-2kb2A:
undetectable		 4dajB-2kb2A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2kb2 BLRP1
(Klebsiella
pneumoniae) 		5 / 11 ALA A  30
LEU A  26
ALA A  25
VAL A  77
LEU A  64
 FMN  A 149 (-3.4A)
FMN  A 149 (-4.0A)
None
None
FMN  A 149 ( 4.1A)
 1.16A 4nqaA-2kb2A:
undetectable		 4nqaA-2kb2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2kb2 BLRP1
(Klebsiella
pneumoniae) 		5 / 12 ALA A  30
LEU A  26
ALA A  25
VAL A  77
LEU A  64
 FMN  A 149 (-3.4A)
FMN  A 149 (-4.0A)
None
None
FMN  A 149 ( 4.1A)
 1.00A 5z12C-2kb2A:
undetectable		 5z12C-2kb2A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2kb2 BLRP1
(Klebsiella
pneumoniae) 		4 / 6 GLN A  49
PHE A  50
LEU A  98
PHE A 103
 None
FMN  A 149 ( 3.1A)
None
None
 1.29A 6nmpC-2kb2A:
undetectable
6nmpJ-2kb2A:
undetectable		 6nmpC-2kb2A:
20.31
6nmpJ-2kb2A:
13.73