SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		5 / 11 GLY A 131
GLU A  25
MET A  26
ASN A 108
ILE A 130
 None
 1.43A 1odiB-2kb3A:
undetectable		 1odiB-2kb3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		5 / 11 GLY A 131
GLU A  25
MET A  26
ASN A 108
ILE A 130
 None
 1.43A 1odiD-2kb3A:
undetectable		 1odiD-2kb3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		4 / 7 ILE A 128
LEU A 135
ARG A  93
THR A  69
 None
 1.00A 1v54N-2kb3A:
undetectable
1v54W-2kb3A:
undetectable		 1v54N-2kb3A:
14.43
1v54W-2kb3A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		4 / 7 ILE A 128
LEU A 135
ARG A  93
THR A  69
 None
 0.99A 2dyrN-2kb3A:
undetectable
2dyrW-2kb3A:
undetectable		 2dyrN-2kb3A:
14.43
2dyrW-2kb3A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		5 / 12 ASP A 103
GLY A 105
GLY A 131
VAL A  83
ASP A  82
 None
 0.88A 2fqyA-2kb3A:
undetectable		 2fqyA-2kb3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		4 / 7 ILE A 128
LEU A 135
ARG A  93
THR A  69
 None
 0.99A 2zxwN-2kb3A:
undetectable
2zxwW-2kb3A:
undetectable		 2zxwN-2kb3A:
14.43
2zxwW-2kb3A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		5 / 10 ILE A 130
ILE A 128
ILE A  78
SER A  76
SER A  86
 None
 1.29A 3o1cA-2kb3A:
undetectable		 3o1cA-2kb3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		4 / 6 GLY A 105
VAL A 104
ASP A 103
THR A 110
 None
 0.90A 3vqrA-2kb3A:
undetectable		 3vqrA-2kb3A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		4 / 5 GLY A 105
VAL A 104
ASP A 103
THR A 110
 None
 0.90A 3vqrB-2kb3A:
undetectable		 3vqrB-2kb3A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		3 / 3 GLY A 105
LEU A 107
HIS A  89
 None
TPO  A  15 ( 2.5A)
None
 0.64A 5u63A-2kb3A:
undetectable		 5u63A-2kb3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		3 / 3 GLY A 105
LEU A 107
HIS A  89
 None
TPO  A  15 ( 2.5A)
None
 0.60A 5u63B-2kb3A:
undetectable		 5u63B-2kb3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		4 / 5 LEU A 135
LEU A  49
GLN A 129
TYR A 111
 None
 1.09A 5uc3A-2kb3A:
undetectable		 5uc3A-2kb3A:
20.95