SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kbb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2kbb TALIN-1
(Mus
musculus) 		5 / 11 LEU A1796
LEU A1776
ALA A1735
MET A1734
LEU A1716
 None
 1.36A 1iiuA-2kbbA:
undetectable		 1iiuA-2kbbA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 2kbb TALIN-1
(Mus
musculus) 		5 / 10 VAL A1706
LEU A1741
LEU A1814
THR A1812
THR A1813
 None
 1.39A 1rj6A-2kbbA:
undetectable		 1rj6A-2kbbA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 2kbb TALIN-1
(Mus
musculus) 		5 / 10 VAL A1706
LEU A1741
LEU A1814
THR A1812
THR A1813
 None
 1.30A 1rj6B-2kbbA:
undetectable		 1rj6B-2kbbA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2kbb TALIN-1
(Mus
musculus) 		5 / 10 LEU A1775
LEU A1716
LEU A1712
ILE A1709
ALA A1735
 None
 1.09A 2bxeB-2kbbA:
3.3		 2bxeB-2kbbA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2kbb TALIN-1
(Mus
musculus) 		4 / 5 LEU A1741
GLN A1764
THR A1765
THR A1704
 None
 1.01A 2zj0B-2kbbA:
undetectable		 2zj0B-2kbbA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2kbb TALIN-1
(Mus
musculus) 		4 / 5 LEU A1741
GLN A1764
THR A1765
THR A1704
 None
 1.08A 2zj0C-2kbbA:
undetectable		 2zj0C-2kbbA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2kbb TALIN-1
(Mus
musculus) 		4 / 4 LEU A1741
GLN A1764
THR A1765
THR A1704
 None
 0.99A 2zj0D-2kbbA:
undetectable		 2zj0D-2kbbA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2kbb TALIN-1
(Mus
musculus) 		4 / 5 LEU A1741
GLN A1764
THR A1765
THR A1704
 None
 1.04A 3ce6B-2kbbA:
undetectable		 3ce6B-2kbbA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2kbb TALIN-1
(Mus
musculus) 		4 / 5 SER A1754
ARG A1690
GLY A1747
GLU A1691
 None
 1.31A 3k9fA-2kbbA:
undetectable
3k9fB-2kbbA:
undetectable
3k9fC-2kbbA:
undetectable		 3k9fA-2kbbA:
15.42
3k9fB-2kbbA:
15.42
3k9fC-2kbbA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 2kbb TALIN-1
(Mus
musculus) 		4 / 7 LEU A1703
GLU A1816
ALA A1817
ALA A1818
 None
 0.82A 3r9tB-2kbbA:
undetectable		 3r9tB-2kbbA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2kbb TALIN-1
(Mus
musculus) 		4 / 5 SER A1754
ARG A1690
GLY A1747
GLU A1691
 None
 1.01A 5btiA-2kbbA:
undetectable
5btiB-2kbbA:
undetectable		 5btiA-2kbbA:
19.85
5btiB-2kbbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2kbb TALIN-1
(Mus
musculus) 		4 / 5 SER A1754
ARG A1690
GLY A1747
GLU A1691
 None
 1.05A 5btiC-2kbbA:
undetectable
5btiD-2kbbA:
undetectable		 5btiC-2kbbA:
19.85
5btiD-2kbbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2kbb TALIN-1
(Mus
musculus) 		5 / 12 TYR A1777
VAL A1807
THR A1811
PHE A1738
LEU A1668
 None
 1.33A 6a93B-2kbbA:
7.6		 6a93B-2kbbA:
19.30