SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kbe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 198
THR A 215
PRO A 216
GLY A 217
 None
 0.72A 1h4oB-2kbeA:
undetectable		 1h4oB-2kbeA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 198
THR A 215
PRO A 216
GLY A 217
 None
 0.72A 1h4oG-2kbeA:
undetectable		 1h4oG-2kbeA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 198
THR A 215
PRO A 216
GLY A 217
 None
 0.73A 1oc3A-2kbeA:
undetectable		 1oc3A-2kbeA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 143
THR A 145
ALA A 147
LEU A 123
LEU A 150
 None
 1.15A 2npnA-2kbeA:
undetectable		 2npnA-2kbeA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 107
GLY A 106
TYR A 108
LEU A  99
PRO A 115
 None
 1.14A 2y7kD-2kbeA:
undetectable		 2y7kD-2kbeA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 267
GLY A 214
ALA A 165
LEU A 230
VAL A 257
 None
 1.02A 3adxB-2kbeA:
undetectable		 3adxB-2kbeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 249
GLY A 217
ALA A 169
ALA A 175
ASP A 239
 None
 1.06A 3keeA-2kbeA:
undetectable		 3keeA-2kbeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 249
GLY A 217
ALA A 169
ALA A 175
ASP A 239
 None
 1.05A 3keeC-2kbeA:
undetectable		 3keeC-2kbeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 249
GLY A 217
ALA A 169
ALA A 175
ASP A 239
 None
 1.02A 3keeD-2kbeA:
undetectable		 3keeD-2kbeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 249
GLY A 217
ALA A 169
ALA A 175
ASP A 239
 None
 0.98A 3sudD-2kbeA:
undetectable		 3sudD-2kbeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 249
GLY A 217
ALA A 169
ALA A 175
ASP A 239
 None
 0.96A 3sueC-2kbeA:
undetectable		 3sueC-2kbeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 239
ASN A 243
SER A 138
 None
 0.84A 4obwA-2kbeA:
3.8		 4obwA-2kbeA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2kbe ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 153
MET A 152
VAL A 156
ASN A 157
 None
 1.27A 5b8iB-2kbeA:
0.0		 5b8iB-2kbeA:
25.10