SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kbq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 7 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.77A 1v55A-2kbqA:
undetectable
1v55J-2kbqA:
undetectable		 1v55A-2kbqA:
8.84
1v55J-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 8 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.76A 1v55N-2kbqA:
undetectable
1v55W-2kbqA:
undetectable		 1v55N-2kbqA:
8.84
1v55W-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 2kbq HARMONIN
(Homo
sapiens) 		3 / 3 ASP A  14
ARG A  10
ASP A  20
 None
 0.90A 1vptA-2kbqA:
undetectable		 1vptA-2kbqA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 8 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.77A 2einA-2kbqA:
undetectable
2einJ-2kbqA:
undetectable		 2einA-2kbqA:
8.84
2einJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 8 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.83A 3abkA-2kbqA:
undetectable
3abkJ-2kbqA:
undetectable		 3abkA-2kbqA:
8.84
3abkJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 8 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.80A 3abmN-2kbqA:
undetectable
3abmW-2kbqA:
undetectable		 3abmN-2kbqA:
8.84
3abmW-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 7 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.80A 3ag3A-2kbqA:
undetectable
3ag3J-2kbqA:
undetectable		 3ag3A-2kbqA:
8.84
3ag3J-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 8 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.80A 3ag3N-2kbqA:
undetectable
3ag3W-2kbqA:
undetectable		 3ag3N-2kbqA:
8.84
3ag3W-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 8 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.78A 3asoN-2kbqA:
undetectable
3asoW-2kbqA:
undetectable		 3asoN-2kbqA:
8.84
3asoW-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2kbq HARMONIN
(Homo
sapiens) 		3 / 3 ASP A  14
ARG A  10
ASP A  20
 None
 0.85A 4fp9D-2kbqA:
undetectable		 4fp9D-2kbqA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2kbq HARMONIN
(Homo
sapiens) 		3 / 3 ASP A  14
ARG A  10
ASP A  20
 None
 0.81A 4fzvA-2kbqA:
undetectable		 4fzvA-2kbqA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 7 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.80A 5b1aA-2kbqA:
undetectable
5b1aJ-2kbqA:
undetectable		 5b1aA-2kbqA:
8.84
5b1aJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 7 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.83A 5b3sA-2kbqA:
undetectable
5b3sJ-2kbqA:
undetectable		 5b3sA-2kbqA:
8.84
5b3sJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2kbq HARMONIN
(Homo
sapiens) 		3 / 3 LEU A  26
LEU A  58
ARG A   3
 None
 0.66A 5hnzB-2kbqA:
undetectable		 5hnzB-2kbqA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 7 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.79A 5iy5A-2kbqA:
undetectable
5iy5J-2kbqA:
undetectable		 5iy5A-2kbqA:
8.84
5iy5J-2kbqA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 7 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.84A 5xdqN-2kbqA:
undetectable
5xdqW-2kbqA:
undetectable		 5xdqN-2kbqA:
8.84
5xdqW-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 7 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.85A 5xdxA-2kbqA:
undetectable
5xdxJ-2kbqA:
undetectable		 5xdxA-2kbqA:
8.84
5xdxJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 7 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.84A 5zcpA-2kbqA:
undetectable
5zcpJ-2kbqA:
undetectable		 5zcpA-2kbqA:
8.84
5zcpJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 8 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.81A 5zcpN-2kbqA:
undetectable
5zcpW-2kbqA:
undetectable		 5zcpN-2kbqA:
8.84
5zcpW-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 7 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.81A 5zcqA-2kbqA:
undetectable
5zcqJ-2kbqA:
undetectable		 5zcqA-2kbqA:
8.84
5zcqJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2kbq HARMONIN
(Homo
sapiens) 		3 / 3 ASP A  14
ARG A  10
ASP A  20
 None
 0.80A 5zvgA-2kbqA:
undetectable		 5zvgA-2kbqA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2kbq HARMONIN
(Homo
sapiens) 		3 / 3 ASP A  14
ARG A  10
ASP A  20
 None
 0.82A 5zvgB-2kbqA:
undetectable		 5zvgB-2kbqA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 7 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.86A 6nmfA-2kbqA:
undetectable
6nmfJ-2kbqA:
undetectable		 6nmfA-2kbqA:
8.84
6nmfJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2kbq HARMONIN
(Homo
sapiens) 		4 / 7 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.84A 6nmpA-2kbqA:
undetectable
6nmpJ-2kbqA:
undetectable		 6nmpA-2kbqA:
8.84
6nmpJ-2kbqA:
23.68