SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2kc3 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 4 THR A  67
LEU A  71
LEU A  78
GLN A  81
 None
 1.18A 1fbmA-2kc3A:
undetectable		 1fbmA-2kc3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 2kc3 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 6 LEU A  78
ALA A 164
SER A  22
THR A  18
 None
 1.06A 1ictB-2kc3A:
undetectable		 1ictB-2kc3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2kc3 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 7 GLN A 101
LEU A 155
ASP A 151
LEU A 148
 None
 0.91A 2qqcB-2kc3A:
undetectable
2qqcC-2kc3A:
undetectable		 2qqcB-2kc3A:
19.46
2qqcC-2kc3A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2kc3 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 7 LEU A 155
ASP A 151
LEU A 148
GLN A 101
 None
 0.87A 2qqcA-2kc3A:
undetectable
2qqcF-2kc3A:
undetectable		 2qqcA-2kc3A:
14.92
2qqcF-2kc3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2kc3 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 7 GLN A 101
LEU A 155
ASP A 151
LEU A 148
 None
 0.91A 2qqcD-2kc3A:
undetectable
2qqcE-2kc3A:
undetectable		 2qqcD-2kc3A:
19.46
2qqcE-2kc3A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2kc3 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 7 LEU A 155
ASP A 151
LEU A 148
GLN A 101
 None
 0.89A 2qqcG-2kc3A:
undetectable
2qqcJ-2kc3A:
undetectable		 2qqcG-2kc3A:
14.92
2qqcJ-2kc3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2kc3 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 7 LEU A 155
ASP A 151
LEU A 148
GLN A 101
 None
 0.92A 2qqcI-2kc3A:
undetectable
2qqcL-2kc3A:
undetectable		 2qqcI-2kc3A:
14.92
2qqcL-2kc3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 2kc3 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 6 LEU A  78
ALA A 164
SER A  22
THR A  18
 None
 0.97A 3cfqA-2kc3A:
undetectable		 3cfqA-2kc3A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 2kc3 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 6 LEU A  78
ALA A 164
SER A  22
THR A  18
 None
 0.97A 4i89A-2kc3A:
undetectable		 4i89A-2kc3A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 2kc3 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 6 LEU A  78
ALA A 164
SER A  22
THR A  18
 None
 0.98A 5bojA-2kc3A:
undetectable		 5bojA-2kc3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 2kc3 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 6 LEU A  78
ALA A 164
SER A  22
THR A  18
 None
 1.03A 5l4iA-2kc3A:
undetectable		 5l4iA-2kc3A:
16.86