SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 2kco 30S RIBOSOMAL
PROTEIN S8E
(Sulfolobus
solfataricus) 		5 / 10 LEU A  82
VAL A 111
ILE A 121
GLY A  94
PRO A  85
 None
 1.26A 1d4sA-2kcoA:
undetectable		 1d4sA-2kcoA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 2kco 30S RIBOSOMAL
PROTEIN S8E
(Sulfolobus
solfataricus) 		4 / 6 LEU A 126
LEU A  82
THR A 104
VAL A  65
 None
 1.05A 4udaA-2kcoA:
undetectable		 4udaA-2kcoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2kco 30S RIBOSOMAL
PROTEIN S8E
(Sulfolobus
solfataricus) 		4 / 4 VAL A 111
ALA A 109
ILE A  78
THR A 104
 None
 1.21A 5e4dB-2kcoA:
undetectable		 5e4dB-2kcoA:
19.52