SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2kcy 30S RIBOSOMAL
PROTEIN S8E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.07A 1rs6A-2kcyA:
undetectable		 1rs6A-2kcyA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2kcy 30S RIBOSOMAL
PROTEIN S8E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.11A 1rs6B-2kcyA:
undetectable		 1rs6B-2kcyA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2kcy 30S RIBOSOMAL
PROTEIN S8E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.19A 1zzqA-2kcyA:
undetectable		 1zzqA-2kcyA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2kcy 30S RIBOSOMAL
PROTEIN S8E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.23A 1zzqB-2kcyA:
undetectable		 1zzqB-2kcyA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2kcy 30S RIBOSOMAL
PROTEIN S8E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 0.99A 1zzuA-2kcyA:
undetectable		 1zzuA-2kcyA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2kcy 30S RIBOSOMAL
PROTEIN S8E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.06A 3n62B-2kcyA:
undetectable		 3n62B-2kcyA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2kcy 30S RIBOSOMAL
PROTEIN S8E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.04A 4d33A-2kcyA:
undetectable		 4d33A-2kcyA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2kcy 30S RIBOSOMAL
PROTEIN S8E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.08A 4d33B-2kcyA:
undetectable		 4d33B-2kcyA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2kcy 30S RIBOSOMAL
PROTEIN S8E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.23A 5vunA-2kcyA:
undetectable		 5vunA-2kcyA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2kcy 30S RIBOSOMAL
PROTEIN S8E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.24A 5vuoB-2kcyA:
undetectable		 5vuoB-2kcyA:
12.80