SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kdi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CD2_A_FOLA307_1 (DIHYDROFOLATE REDUCTASE)	2kdi	UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN (Saccharomyces cerevisiae)	3 / 3	GLU A 43 ILE A 39 ARG A 81	None	0.84A	1cd2A-2kdiA: undetectable	1cd2A-2kdiA: 21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2FCN_A_DVAA35_0 (UBIQUITIN)	2kdi	UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN (Saccharomyces cerevisiae)	4 / 4	GLN A 40 GLU A 43 ILE A 45 PRO A 46	None	1.14A	2fcnA-2kdiA: 10.7	2fcnA-2kdiA: 80.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FJ1_A_CTCA222_0 (TETRACYCLINE REPRESSOR PROTEIN CLASS D)	2kdi	UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN (Saccharomyces cerevisiae)	5 / 12	SER A 66 THR A 64 LEU A 24 ILE A 12 SER A 74	None	1.25A	2fj1A-2kdiA: undetectable	2fj1A-2kdiA: 22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HZN_D_ACTD229_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2kdi	UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN (Saccharomyces cerevisiae)	4 / 4	ASP A 41 GLY A 44 LYS A 42 GLU A 43	None	1.31A	3hznD-2kdiA: undetectable	3hznD-2kdiA: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKX_C_STRC601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	2kdi	UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN (Saccharomyces cerevisiae)	4 / 5	ILE A 39 ARG A 81 ASP A 61 VAL A 26	None	1.14A	4nkxC-2kdiA: undetectable	4nkxC-2kdiA: 14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKX_D_STRD601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	2kdi	UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN (Saccharomyces cerevisiae)	4 / 5	ILE A 39 ARG A 81 ASP A 61 VAL A 26	None	1.17A	4nkxD-2kdiA: undetectable	4nkxD-2kdiA: 14.90

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1CD2_A_FOLA307_1","DIHYDROFOLATE REDUCTASE","2kdi","UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN","Saccharomyces cerevisiae",3,"GLU A  43;ILE A  39;ARG A  81","None","0.84A","1cd2A-2kdiA:undetectable","1cd2A-2kdiA:21.67"],["2FCN_A_DVAA35_0","UBIQUITIN","2kdi","UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN","Saccharomyces cerevisiae",4,"GLN A  40;GLU A  43;ILE A  45;PRO A  46","None","1.14A","2fcnA-2kdiA:10.7","2fcnA-2kdiA:80.00"],["2FJ1_A_CTCA222_0","TETRACYCLINE REPRESSOR PROTEIN CLASS D","2kdi","UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN","Saccharomyces cerevisiae",5,"SER A  66;THR A  64;LEU A  24;ILE A  12;SER A  74","None","1.25A","2fj1A-2kdiA:undetectable","2fj1A-2kdiA:22.84"],["3HZN_D_ACTD229_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2kdi","UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN","Saccharomyces cerevisiae",4,"ASP A  41;GLY A  44;LYS A  42;GLU A  43","None","1.31A","3hznD-2kdiA:undetectable","3hznD-2kdiA:19.73"],["4NKX_C_STRC601_2","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","2kdi","UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN","Saccharomyces cerevisiae",4,"ILE A  39;ARG A  81;ASP A  61;VAL A  26","None","1.14A","4nkxC-2kdiA:undetectable","4nkxC-2kdiA:14.90"],["4NKX_D_STRD601_2","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","2kdi","UBIQUITIN, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27 FUSION PROTEIN","Saccharomyces cerevisiae",4,"ILE A  39;ARG A  81;ASP A  61;VAL A  26","None","1.17A","4nkxD-2kdiA:undetectable","4nkxD-2kdiA:14.90"]]