SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kdy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		4 / 8 LEU A  69
SER A  80
GLN A 107
ASP A 139
 None
 1.09A 1ig3A-2kdyA:
undetectable
1ig3B-2kdyA:
undetectable		 1ig3A-2kdyA:
22.30
1ig3B-2kdyA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		3 / 3 TYR A 203
ARG A 159
GLN A 261
 None
 0.94A 1tw4A-2kdyA:
3.4		 1tw4A-2kdyA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		4 / 7 GLU A 208
PHE A 135
ILE A 137
PHE A 163
 None
 0.99A 2qmzA-2kdyA:
undetectable
2qmzB-2kdyA:
undetectable		 2qmzA-2kdyA:
22.74
2qmzB-2kdyA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		5 / 12 ALA A 162
VAL A 197
TYR A 228
GLY A 256
ILE A 255
 None
 1.40A 3a65A-2kdyA:
undetectable		 3a65A-2kdyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		5 / 8 GLY A 169
ALA A 168
ASP A 167
LEU A 172
VAL A  14
 None
 1.32A 3em6A-2kdyA:
undetectable		 3em6A-2kdyA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		4 / 8 PHE A 135
ALA A 162
PHE A 163
ALA A 244
 None
 0.85A 3t3sD-2kdyA:
undetectable		 3t3sD-2kdyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		4 / 7 LEU A 199
GLY A 256
ALA A 162
PHE A 163
 None
 0.89A 3tehB-2kdyA:
undetectable		 3tehB-2kdyA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		3 / 3 TYR A 105
ARG A  81
SER A  80
 None
 1.10A 4dr2I-2kdyA:
undetectable
4dr2J-2kdyA:
undetectable		 4dr2I-2kdyA:
20.00
4dr2J-2kdyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		4 / 7 ALA A 114
GLY A 169
ILE A 255
GLY A 256
 None
 0.62A 4eatA-2kdyA:
undetectable		 4eatA-2kdyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		5 / 8 LEU A 230
GLY A 231
VAL A 240
LEU A 172
GLY A 256
 None
 1.13A 4zauA-2kdyA:
undetectable		 4zauA-2kdyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		5 / 12 ASP A  34
GLY A  72
ASN A  70
LEU A  69
LYS A  61
 None
 1.29A 5kbwA-2kdyA:
undetectable		 5kbwA-2kdyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001
(Neisseria
meningitidis) 		4 / 8 LEU A  52
LEU A  69
ILE A 137
THR A 113
 None
 1.03A 5ljbA-2kdyA:
2.0		 5ljbA-2kdyA:
19.16