SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ke5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		6 / 12 PHE A  83
THR A  69
GLY A  88
GLY A  86
SER A  85
GLU A 175
 None
 1.35A 1vq1B-2ke5A:
undetectable		 1vq1B-2ke5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		4 / 7 MET A 173
ARG A  52
PRO A 122
GLY A  86
 None
 1.19A 2pnjB-2ke5A:
4.9		 2pnjB-2ke5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		5 / 11 THR A  31
ASN A 128
LEU A  67
ILE A  18
LEU A  72
 None
GNP  A 500 (-4.7A)
None
None
None
 1.26A 3a50C-2ke5A:
undetectable		 3a50C-2ke5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		5 / 12 THR A  31
ASN A 128
LEU A  67
ILE A  18
LEU A  72
 None
GNP  A 500 (-4.7A)
None
None
None
 1.24A 3a50E-2ke5A:
undetectable		 3a50E-2ke5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		4 / 6 MET A 173
ARG A  52
PRO A 122
GLY A  86
 None
 1.21A 3aqiA-2ke5A:
4.3		 3aqiA-2ke5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		4 / 6 MET A 173
ARG A  52
PRO A 122
GLY A  86
 None
 1.25A 3aqiB-2ke5A:
0.4		 3aqiB-2ke5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		5 / 11 VAL A  17
GLY A  88
ILE A 121
LYS A 120
PRO A 122
 None
 1.19A 3bjwB-2ke5A:
undetectable		 3bjwB-2ke5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		5 / 11 VAL A  17
GLY A  88
ILE A 121
LYS A 120
PRO A 122
 None
 1.30A 3bjwE-2ke5A:
undetectable		 3bjwE-2ke5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		5 / 11 VAL A  17
GLY A  88
ILE A 121
LYS A 120
PRO A 122
 None
 1.14A 3bjwH-2ke5A:
undetectable		 3bjwH-2ke5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		3 / 3 TYR A  43
ASP A  68
ASP A  49
 None
 0.94A 3ou7B-2ke5A:
undetectable		 3ou7B-2ke5A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		4 / 4 LEU A  91
GLY A  21
SER A  22
SER A 100
 None
 1.25A 5uunB-2ke5A:
undetectable		 5uunB-2ke5A:
18.81