SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ke7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Y0X_X_T44X500_2 (THYROID HORMONE RECEPTOR BETA-1)	2ke7	ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B (Homo sapiens)	4 / 5	ILE A 871 SER A 861 ARG A 866 LEU A 868	None	1.04A	1y0xX-2ke7A: undetectable	1y0xX-2ke7A: 18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KK6_B_CELB1701_2 (PROSTAGLANDIN G/H SYNTHASE 1)	2ke7	ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B (Homo sapiens)	4 / 6	VAL A 840 SER A 822 ALA A 870 LEU A 874	None	0.78A	3kk6B-2ke7A: undetectable	3kk6B-2ke7A: 11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACA_B_DXCB1473_0 (TRANSLATION ELONGATION FACTOR SELB)	2ke7	ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B (Homo sapiens)	5 / 9	ILE A 823 GLY A 824 VAL A 840 GLN A 818 GLY A 817	None	0.98A	4acaB-2ke7A: undetectable 4acaC-2ke7A: undetectable	4acaB-2ke7A: 10.59 4acaC-2ke7A: 10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HI2_A_BAXA801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2ke7	ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B (Homo sapiens)	5 / 8	VAL A 847 ILE A 856 ILE A 871 ILE A 858 ASP A 850	None	1.50A	5hi2A-2ke7A: undetectable	5hi2A-2ke7A: 18.64

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Y0X_X_T44X500_2","THYROID HORMONE RECEPTOR BETA-1","2ke7","ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B","Homo sapiens",4,"ILE A 871;SER A 861;ARG A 866;LEU A 868","None","1.04A","1y0xX-2ke7A:undetectable","1y0xX-2ke7A:18.68"],["3KK6_B_CELB1701_2","PROSTAGLANDIN G\/H SYNTHASE 1","2ke7","ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B","Homo sapiens",4,"VAL A 840;SER A 822;ALA A 870;LEU A 874","None","0.78A","3kk6B-2ke7A:undetectable","3kk6B-2ke7A:11.79"],["4ACA_B_DXCB1473_0","TRANSLATION ELONGATION FACTOR SELB","2ke7","ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B","Homo sapiens",5,"ILE A 823;GLY A 824;VAL A 840;GLN A 818;GLY A 817","None","0.98A","4acaB-2ke7A:undetectable;4acaC-2ke7A:undetectable","4acaB-2ke7A:10.59;4acaC-2ke7A:10.59"],["5HI2_A_BAXA801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","2ke7","ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B","Homo sapiens",5,"VAL A 847;ILE A 856;ILE A 871;ILE A 858;ASP A 850","None","1.50A","5hi2A-2ke7A:undetectable","5hi2A-2ke7A:18.64"]]