SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 2kep GENERAL SECRETION
PATHWAY PROTEIN G
(Pseudomonas
aeruginosa) 		6 / 12 LEU A 100
ASP A 124
GLY A 144
ILE A 143
ALA A  56
ILE A  57
 None
 1.40A 1rl8B-2kepA:
undetectable		 1rl8B-2kepA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2kep GENERAL SECRETION
PATHWAY PROTEIN G
(Pseudomonas
aeruginosa) 		5 / 8 LEU A 103
ASP A  53
ALA A  50
GLY A 144
LEU A 100
 None
 1.36A 2o4nB-2kepA:
undetectable		 2o4nB-2kepA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2kep GENERAL SECRETION
PATHWAY PROTEIN G
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 135
ALA A 141
ASP A 140
ASN A 139
VAL A  47
ILE A 143
 None
 1.40A 2qakA-2kepA:
undetectable		 2qakA-2kepA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 2kep GENERAL SECRETION
PATHWAY PROTEIN G
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  82
LEU A  81
GLY A  98
ILE A  57
SER A 127
 None
 1.32A 3bjwE-2kepA:
undetectable		 3bjwE-2kepA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2kep GENERAL SECRETION
PATHWAY PROTEIN G
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 144
ALA A  58
ASP A  53
ALA A  50
ASP A 142
 None
 1.44A 4df3A-2kepA:
undetectable		 4df3A-2kepA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2kep GENERAL SECRETION
PATHWAY PROTEIN G
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 135
GLU A 134
ASP A 131
ASP A 138
 None
 0.95A 4uckB-2kepA:
undetectable		 4uckB-2kepA:
14.69