SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kfk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2kfk CELL DIVISION
CONTROL PROTEIN 24
(Saccharomyces
cerevisiae) 		4 / 6 ASN B 134
ASP B 127
GLY B 161
ILE B 133
 None
 0.88A 1n49D-2kfkB:
undetectable		 1n49D-2kfkB:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2kfk BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 ALA A  35
TYR A  12
ILE A  34
ASP A  77
 None
 1.26A 1upfA-2kfkA:
undetectable		 1upfA-2kfkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2kfk BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 ALA A  35
TYR A  12
ILE A  34
ASP A  77
 None
 1.10A 1upfC-2kfkA:
undetectable		 1upfC-2kfkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 2kfk CELL DIVISION
CONTROL PROTEIN 24
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 118
LEU B 119
ILE B 109
ARG B 108
 None
 1.04A 2rlfA-2kfkB:
undetectable
2rlfB-2kfkB:
undetectable		 2rlfA-2kfkB:
20.25
2rlfB-2kfkB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2kfk BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  10
GLY A  52
ASP A  15
ILE A  34
LEU A  19
 None
 1.20A 3eeoA-2kfkA:
undetectable		 3eeoA-2kfkA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2kfk BUD EMERGENCE
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  11
LYS A  72
LYS A   9
 None
 1.19A 5dbyA-2kfkA:
undetectable		 5dbyA-2kfkA:
9.21