SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3V_A_TOPA193_1 (DIHYDROFOLATE REDUCTASE)	2kfs	CONSERVED HYPOTHETICAL REGULATORY PROTEIN (Mycobacterium tuberculosis)	4 / 5	ASP A 21 ILE A 66 PRO A 67 PHE A 70	None	1.09A	3s3vA-2kfsA: undetectable	3s3vA-2kfsA: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F93_B_SANB3004_1 (U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE)	2kfs	CONSERVED HYPOTHETICAL REGULATORY PROTEIN (Mycobacterium tuberculosis)	4 / 8	HIS A 130 GLN A 76 GLY A 75 SER A 74	None	0.97A	4f93B-2kfsA: undetectable	4f93B-2kfsA: 7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KIC_B_SAMB401_1 (METHYLTRANSFERASE MPPJ)	2kfs	CONSERVED HYPOTHETICAL REGULATORY PROTEIN (Mycobacterium tuberculosis)	3 / 3	ARG A 51 ASP A 95 ASP A 21	None	0.88A	4kicB-2kfsA: undetectable	4kicB-2kfsA: 21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	2kfs	CONSERVED HYPOTHETICAL REGULATORY PROTEIN (Mycobacterium tuberculosis)	5 / 12	LEU A 23 VAL A 58 PRO A 67 HIS A 130 GLY A 75	None	1.40A	6mn8A-2kfsA: undetectable	6mn8A-2kfsA: 14.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3S3V_A_TOPA193_1","DIHYDROFOLATE REDUCTASE","2kfs","CONSERVED HYPOTHETICAL REGULATORY PROTEIN","Mycobacterium tuberculosis",4,"ASP A  21;ILE A  66;PRO A  67;PHE A  70","None","1.09A","3s3vA-2kfsA:undetectable","3s3vA-2kfsA:17.86"],["4F93_B_SANB3004_1","U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE","2kfs","CONSERVED HYPOTHETICAL REGULATORY PROTEIN","Mycobacterium tuberculosis",4,"HIS A 130;GLN A  76;GLY A  75;SER A  74","None","0.97A","4f93B-2kfsA:undetectable","4f93B-2kfsA:7.08"],["4KIC_B_SAMB401_1","METHYLTRANSFERASE MPPJ","2kfs","CONSERVED HYPOTHETICAL REGULATORY PROTEIN","Mycobacterium tuberculosis",3,"ARG A  51;ASP A  95;ASP A  21","None","0.88A","4kicB-2kfsA:undetectable","4kicB-2kfsA:21.81"],["6MN8_A_HFGA603_0","UNCHARACTERIZED PROTEIN","2kfs","CONSERVED HYPOTHETICAL REGULATORY PROTEIN","Mycobacterium tuberculosis",5,"LEU A  23;VAL A  58;PRO A  67;HIS A 130;GLY A  75","None","1.40A","6mn8A-2kfsA:undetectable","6mn8A-2kfsA:14.03"]]