SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kfu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2kfu RV1827 PTHR 22
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  58
PHE A 146
ARG A 123
 None
 0.78A 1xdkB-2kfuA:
undetectable		 1xdkB-2kfuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2kfu RV1827 PTHR 22
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  58
PHE A 146
ARG A 123
 None
 0.78A 1xdkF-2kfuA:
undetectable		 1xdkF-2kfuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 2kfu RV1827 PTHR 22
(Mycobacterium
tuberculosis) 		5 / 9 PHE A  70
VAL A  60
ILE A 139
GLY A 140
THR A  93
 None
 1.33A 3t3rB-2kfuA:
undetectable		 3t3rB-2kfuA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2kfu RV1827 PTHR 22
(Mycobacterium
tuberculosis) 		5 / 9 PHE A  70
VAL A  60
ILE A 139
GLY A 140
THR A  93
 None
 1.37A 3t3rC-2kfuA:
undetectable		 3t3rC-2kfuA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2kfu RV1827 PTHR 22
(Mycobacterium
tuberculosis) 		4 / 8 ARG A  96
VAL A 121
VAL A 113
GLY A 114
 None
 0.94A 4mk4A-2kfuA:
undetectable		 4mk4A-2kfuA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2kfu RV1827 PTHR 22
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  89
THR A  77
ALA A  79
SER A 115
 None
 0.65A 4pwjA-2kfuA:
undetectable		 4pwjA-2kfuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 2kfu RV1827 PTHR 22
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  89
THR A  77
ALA A  79
SER A 115
 None
 0.64A 4pwjB-2kfuA:
undetectable		 4pwjB-2kfuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2kfu RV1827 PTHR 22
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  89
THR A  77
ALA A  79
SER A 115
 None
 0.65A 5bojB-2kfuA:
undetectable		 5bojB-2kfuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2kfu RV1827 PTHR 22
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  88
GLY A  80
VAL A 110
VAL A  60
LEU A  58
 None
 1.09A 5kocA-2kfuA:
undetectable		 5kocA-2kfuA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2kfu RV1827 PTHR 22
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  88
GLY A  80
VAL A 110
VAL A  60
LEU A  58
 None
 1.10A 5kocB-2kfuA:
undetectable		 5kocB-2kfuA:
18.64