SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 2kfw FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD
(Escherichia
coli) 		5 / 10 HIS A 153
THR A 143
GLU A 144
GLU A 146
ASP A   6
 None
 1.47A 2dttA-2kfwA:
undetectable
2dttC-2kfwA:
undetectable		 2dttA-2kfwA:
20.92
2dttC-2kfwA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 2kfw FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD
(Escherichia
coli) 		4 / 7 LEU A  22
VAL A  21
TYR A  13
GLU A  25
 None
 1.04A 4lb2A-2kfwA:
undetectable		 4lb2A-2kfwA:
16.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2kfw FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD
(Escherichia
coli) 		5 / 10 LEU A  32
LEU A  41
ILE A  42
LEU A  45
TYR A  68
 None
 1.00A 4odoA-2kfwA:
12.2		 4odoA-2kfwA:
41.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2kfw FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD
(Escherichia
coli) 		5 / 10 LEU A  32
LEU A  41
ILE A  42
LEU A  45
TYR A  68
 None
 1.05A 4odoB-2kfwA:
11.9		 4odoB-2kfwA:
41.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2kfw FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD
(Escherichia
coli) 		5 / 10 LEU A  32
LEU A  41
ILE A  42
LEU A  45
TYR A  68
 None
 0.98A 4odoC-2kfwA:
11.9		 4odoC-2kfwA:
41.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 2kfw FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD
(Escherichia
coli) 		5 / 11 LEU A  32
LEU A  41
ILE A  42
LEU A  45
TYR A  68
 None
 0.95A 4odrA-2kfwA:
11.8
4odrB-2kfwA:
11.8		 4odrA-2kfwA:
31.12
4odrB-2kfwA:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 2kfw FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD
(Escherichia
coli) 		5 / 11 LEU A  41
ILE A  42
LEU A  45
TYR A  68
PHE A 132
 None
 1.09A 4odrA-2kfwA:
11.8
4odrB-2kfwA:
11.8		 4odrA-2kfwA:
31.12
4odrB-2kfwA:
31.12