SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  16
THR A  17
PRO A  15
 None
 0.83A 1a7yA-2kgyA:
undetectable		 1a7yA-2kgyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  16
THR A  17
PRO A  15
 None
 0.82A 1i3wF-2kgyA:
undetectable		 1i3wF-2kgyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  17
PRO A  15
THR A  16
 None
 0.82A 1mnvD-2kgyA:
undetectable		 1mnvD-2kgyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  16
THR A  17
PRO A  15
 None
 0.78A 1mnvD-2kgyA:
undetectable		 1mnvD-2kgyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  16
THR A  17
PRO A  15
 None
 0.80A 1qfiA-2kgyA:
undetectable		 1qfiA-2kgyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  17
PRO A  15
THR A  16
 None
 0.82A 1unjF-2kgyA:
undetectable		 1unjF-2kgyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  16
THR A  17
PRO A  15
 None
 0.82A 1unjF-2kgyA:
undetectable		 1unjF-2kgyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  43
THR A  35
ALA A  45
ALA A  44
 None
 0.78A 3ns1C-2kgyA:
undetectable		 3ns1C-2kgyA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  17
PRO A  15
THR A  16
 None
 0.82A 4hivD-2kgyA:
undetectable		 4hivD-2kgyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 GLU A  31
GLU A  59
GLU A  82
TYR A  21
 None
 1.20A 4mj8A-2kgyA:
undetectable
4mj8C-2kgyA:
undetectable		 4mj8A-2kgyA:
18.50
4mj8C-2kgyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  85
GLY A  24
ALA A  27
ALA A  45
VAL A  73
 None
 1.06A 4nkxC-2kgyA:
undetectable		 4nkxC-2kgyA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2kgy POSSIBLE EXPORTED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  85
GLY A  24
ALA A  27
ALA A  45
VAL A  73
 None
 1.07A 4nkxD-2kgyA:
undetectable		 4nkxD-2kgyA:
12.09