SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kh2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2kh2 SCFV
(Mus
musculus) 		3 / 3 TRP B 234
ARG B 173
THR B 233
 None
 1.01A 1df7A-2kh2B:
undetectable		 1df7A-2kh2B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2kh2 SCFV
(Mus
musculus) 		4 / 8 ARG B 227
ASN B 203
SER B 159
ARG B 160
 None
 1.01A 1u1jA-2kh2B:
undetectable		 1u1jA-2kh2B:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2kh2 SCFV
(Mus
musculus) 		5 / 8 GLY B 183
GLY B 184
GLY B 185
SER B 181
ILE B 199
 None
 0.84A 1yajC-2kh2B:
undetectable		 1yajC-2kh2B:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2kh2 SCFV
(Mus
musculus) 		4 / 5 VAL B  19
ILE B  21
VAL B 104
THR B 102
 None
 0.71A 4xdtA-2kh2B:
undetectable		 4xdtA-2kh2B:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2kh2 SCFV
(Mus
musculus) 		4 / 5 TYR B 224
GLY B 241
THR B 242
GLY B 116
 None
 0.84A 5jlcA-2kh2B:
undetectable		 5jlcA-2kh2B:
17.79