SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 10 ASP A 182
ILE A 169
GLY A 374
ILE A 373
VAL A 381
 None
 1.07A 1d4yA-2khoA:
undetectable		 1d4yA-2khoA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 9 ALA A 153
GLY A 158
ILE A 160
ILE A  69
ILE A  73
 None
 0.78A 1hshB-2khoA:
undetectable		 1hshB-2khoA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 8 ALA A 153
GLY A 158
ILE A 160
ILE A  69
ILE A  73
 None
 0.79A 1hshD-2khoA:
undetectable		 1hshD-2khoA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 12 ALA A 465
THR A 428
SER A 427
ILE A 472
LEU A 459
 None
 1.08A 1rg7A-2khoA:
undetectable		 1rg7A-2khoA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 10 ASP A 182
ILE A 169
GLY A 374
ILE A 373
VAL A 381
 None
 0.94A 1t3rA-2khoA:
undetectable		 1t3rA-2khoA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		4 / 4 LYS A 452
LEU A 507
LEU A 397
SER A 398
 None
 1.35A 1tz8D-2khoA:
0.2		 1tz8D-2khoA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 11 ASP A 182
ILE A 169
GLY A 374
ILE A 373
VAL A 381
 None
 1.02A 2o4pA-2khoA:
undetectable		 2o4pA-2khoA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 12 ASP A  85
THR A 199
GLY A 198
GLY A 197
THR A  12
 None
 1.20A 2uvnA-2khoA:
undetectable		 2uvnA-2khoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 8 GLY A 374
ALA A 375
GLY A 380
LEU A 382
VAL A 165
 None
 1.33A 3em6A-2khoA:
undetectable		 3em6A-2khoA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		4 / 8 ASN A 170
THR A 173
LEU A 177
ALA A 375
 None
 0.98A 3kp6A-2khoA:
2.9		 3kp6A-2khoA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 11 VAL A 440
PHE A 426
GLY A 406
GLY A 405
ASN A 537
 None
 1.27A 3owxA-2khoA:
undetectable
3owxB-2khoA:
undetectable		 3owxA-2khoA:
19.31
3owxB-2khoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		6 / 12 ILE A 169
ILE A 373
GLY A 180
ASP A 182
ASP A 336
ILE A 190
 None
 1.08A 3tneB-2khoA:
undetectable		 3tneB-2khoA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 12 VAL A  16
ILE A   5
ILE A  40
GLU A 118
VAL A 135
 None
 1.18A 4a97B-2khoA:
2.9
4a97C-2khoA:
2.9		 4a97B-2khoA:
19.32
4a97C-2khoA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		4 / 5 LYS A 577
LEU A 576
GLU A 573
LEU A 543
 None
 1.35A 4k4yA-2khoA:
undetectable		 4k4yA-2khoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		4 / 4 LYS A 577
LEU A 576
GLU A 573
LEU A 543
 None
 1.35A 4k4yE-2khoA:
undetectable		 4k4yE-2khoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		4 / 5 LYS A 577
LEU A 576
GLU A 573
LEU A 543
 None
 1.35A 4k4yI-2khoA:
undetectable		 4k4yI-2khoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 12 LEU A   9
ASP A 368
VAL A 371
GLY A 196
PRO A 143
 None
 1.02A 4njuA-2khoA:
undetectable		 4njuA-2khoA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 12 LEU A   9
ASP A 368
VAL A 371
GLY A 196
PRO A 143
 None
 1.03A 4njuC-2khoA:
undetectable		 4njuC-2khoA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		6 / 11 ASP A 182
GLY A 180
ILE A 169
GLY A 374
ILE A 373
VAL A 381
 None
 1.44A 4q1xA-2khoA:
undetectable		 4q1xA-2khoA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		4 / 5 THR A  12
GLY A 196
GLU A 230
HIS A 226
 None
 1.02A 5c0oH-2khoA:
undetectable		 5c0oH-2khoA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		3 / 3 THR A 410
SER A 398
ASP A 393
 None
 0.78A 5kvaA-2khoA:
undetectable		 5kvaA-2khoA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 2kho HEAT SHOCK PROTEIN
70
(Escherichia
coli) 		5 / 12 LEU A 163
ALA A 161
ILE A 140
LYS A 166
ALA A 138
 None
 1.32A 5xiwD-2khoA:
undetectable		 5xiwD-2khoA:
9.32