SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ki7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		5 / 11 ASP A  72
VAL A  70
GLY A 110
ILE A  95
ILE A  80
 None
 0.93A 1t3rB-2ki7A:
undetectable		 1t3rB-2ki7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
RIBONUCLEASE P
PROTEIN COMPONENT 4
(Pyrococcus
furiosus) 		5 / 12 ALA B  25
VAL B  28
ILE A  71
ASP A  72
PHE A  30
 None
 1.15A 2v95A-2ki7B:
undetectable		 2v95A-2ki7B:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		5 / 9 ASP A  72
VAL A  70
GLY A 110
ILE A  95
ILE A  80
 None
 0.95A 3ekvB-2ki7A:
undetectable		 3ekvB-2ki7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		5 / 10 ASP A  72
VAL A  70
GLY A 110
ILE A  95
ILE A  80
 None
 0.90A 3nu6A-2ki7A:
undetectable		 3nu6A-2ki7A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		5 / 10 ASP A  72
VAL A  70
GLY A 110
ILE A  95
ILE A  80
 None
 0.97A 3nujA-2ki7A:
undetectable		 3nujA-2ki7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
RIBONUCLEASE P
PROTEIN COMPONENT 4
(Pyrococcus
furiosus) 		5 / 10 ILE A  49
ALA B  25
PHE A  30
SER A  19
ILE A  71
 None
 1.29A 3qgtA-2ki7A:
undetectable		 3qgtA-2ki7A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
RIBONUCLEASE P
PROTEIN COMPONENT 4
(Pyrococcus
furiosus) 		3 / 4 SER B  32
GLY A  50
GLU A  67
 None
 0.63A 3raeA-2ki7B:
undetectable
3raeC-2ki7B:
undetectable		 3raeA-2ki7B:
11.51
3raeC-2ki7B:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		4 / 8 VAL A  70
VAL A  53
ILE A 106
ILE A  43
 None
 0.75A 3warA-2ki7A:
undetectable		 3warA-2ki7A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		5 / 12 ILE A  95
ILE A  80
LEU A  48
LEU A 113
ILE A 108
 None
 1.06A 4m2xC-2ki7A:
undetectable		 4m2xC-2ki7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		5 / 12 ILE A  95
ILE A  80
LEU A  48
LEU A 113
ILE A 108
 None
 1.06A 4m2xE-2ki7A:
undetectable		 4m2xE-2ki7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		5 / 11 ASP A  72
VAL A  70
GLY A 110
ILE A  95
ILE A  80
 None
 0.91A 4njtA-2ki7A:
undetectable		 4njtA-2ki7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 4
(Pyrococcus
furiosus) 		5 / 12 ALA B  50
ASP B  19
GLU B  26
ALA B  25
ALA B  43
 None
 0.95A 4pclA-2ki7B:
undetectable		 4pclA-2ki7B:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		5 / 10 ASP A  72
VAL A  70
GLY A 110
ILE A  95
ILE A  80
 None
 0.89A 4q1wB-2ki7A:
undetectable		 4q1wB-2ki7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		5 / 11 ASP A  72
VAL A  70
GLY A 110
ILE A  95
ILE A  80
 None
 0.84A 4rvjA-2ki7A:
undetectable		 4rvjA-2ki7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		5 / 11 ASP A  72
VAL A  70
GLY A 110
ILE A  95
ILE A  80
 None
 0.86A 4rvjC-2ki7A:
undetectable		 4rvjC-2ki7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
RIBONUCLEASE P
PROTEIN COMPONENT 4
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 SER B  32
SER A  19
PHE A  30
 None
 0.90A 5mugA-2ki7B:
undetectable		 5mugA-2ki7B:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
(Pyrococcus
furiosus) 		4 / 6 PRO A  90
VAL A  79
VAL A  86
TYR A  20
 None
 0.93A 5pbeA-2ki7A:
undetectable		 5pbeA-2ki7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
RIBONUCLEASE P
PROTEIN COMPONENT 4
(Pyrococcus
furiosus) 		3 / 3 ARG A  37
ARG A  35
ARG B  17
 None
 0.91A 5vcgA-2ki7A:
undetectable		 5vcgA-2ki7A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
RIBONUCLEASE P
PROTEIN COMPONENT 4
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 5 ILE A  23
PHE A  30
TYR B  39
ARG B  38
 None
 1.27A 5z84N-2ki7A:
undetectable
5z84W-2ki7A:
undetectable		 5z84N-2ki7A:
12.26
5z84W-2ki7A:
19.51