SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ki8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2ki8 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE,
SUBUNIT D (FWDD-2)
(Archaeoglobus
fulgidus) 		5 / 12 VAL A  83
ASN A  53
GLY A  31
ALA A 104
VAL A 107
 None
 0.99A 1jg4A-2ki8A:
undetectable		 1jg4A-2ki8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2ki8 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE,
SUBUNIT D (FWDD-2)
(Archaeoglobus
fulgidus) 		5 / 11 VAL A  75
VAL A  28
GLU A 128
LEU A  67
ILE A  57
 None
 1.49A 1t6zA-2ki8A:
undetectable		 1t6zA-2ki8A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 2ki8 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE,
SUBUNIT D (FWDD-2)
(Archaeoglobus
fulgidus) 		4 / 6 LEU A 140
ALA A 143
LEU A 141
SER A 146
 None
 1.23A 4d7bB-2ki8A:
undetectable		 4d7bB-2ki8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2ki8 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE,
SUBUNIT D (FWDD-2)
(Archaeoglobus
fulgidus) 		5 / 12 GLU A  27
ILE A  57
LEU A  65
ASP A  61
GLY A  94
 None
 1.19A 4o1eA-2ki8A:
undetectable		 4o1eA-2ki8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 2ki8 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE,
SUBUNIT D (FWDD-2)
(Archaeoglobus
fulgidus) 		4 / 6 LEU A 140
ALA A 143
LEU A 141
SER A 146
 None
 1.29A 5l4iB-2ki8A:
undetectable		 5l4iB-2ki8A:
21.66