SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 2kif O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Vibrio
parahaemolyticus) 		5 / 12 GLY A  31
ALA A  30
ILE A  12
GLY A  24
ILE A   8
 None
 0.95A 1hshC-2kifA:
undetectable		 1hshC-2kifA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2kif O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Vibrio
parahaemolyticus) 		3 / 3 LYS A  75
ASN A  59
ASP A  72
 None
 0.88A 4o1eA-2kifA:
undetectable		 4o1eA-2kifA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 2kif O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Vibrio
parahaemolyticus) 		4 / 8 ALA A  36
VAL A  39
GLU A  25
LYS A  28
 None
 0.89A 4zbqA-2kifA:
undetectable		 4zbqA-2kifA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2kif O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Vibrio
parahaemolyticus) 		3 / 3 LYS A  41
LEU A  52
ILE A  26
 None
 0.72A 5kc0A-2kifA:
undetectable		 5kc0A-2kifA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2kif O6-METHYLGUANINE-DNA
METHYLTRANSFERASE
(Vibrio
parahaemolyticus) 		3 / 3 LYS A  41
LEU A  52
ILE A  26
 None
 0.79A 5kc4A-2kifA:
undetectable		 5kc4A-2kifA:
20.21