SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM
(Mus
musculus) 		5 / 12 LEU A 106
LEU A  59
LEU A  57
GLY A  28
LEU A  30
 None
 1.20A 1g50B-2kigA:
undetectable		 1g50B-2kigA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM
(Mus
musculus) 		5 / 11 LEU A 106
LEU A  59
LEU A  57
GLY A  28
LEU A  30
 None
 1.20A 1g50C-2kigA:
undetectable		 1g50C-2kigA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM
(Mus
musculus) 		4 / 6 LEU A  41
GLY A  28
ILE A  67
HIS A  62
 None
 0.79A 1yajF-2kigA:
undetectable		 1yajF-2kigA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM
(Mus
musculus) 		5 / 11 LEU A 106
LEU A  59
LEU A  57
GLY A  28
LEU A  30
 None
 1.27A 3uudA-2kigA:
undetectable		 3uudA-2kigA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM
(Mus
musculus) 		4 / 5 PHE A 126
LEU A  80
ILE A  24
VAL A  23
 None
 0.88A 3wrkA-2kigA:
undetectable		 3wrkA-2kigA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM
(Mus
musculus) 		5 / 11 SER A  38
VAL A  72
LEU A  40
ALA A  11
THR A  15
 None
 1.11A 4e0fA-2kigA:
undetectable		 4e0fA-2kigA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM
(Mus
musculus) 		5 / 12 LEU A 127
GLY A  42
ALA A 133
VAL A  78
VAL A 104
 None
 1.08A 4wnwB-2kigA:
undetectable		 4wnwB-2kigA:
18.92