SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 2kik ARTIFICIAL DIIRON
PROTEIN
(-) 		3 / 3 ASN A  26
LEU A  21
HIS A  25
 None
 0.59A 2q6fB-2kikA:
undetectable		 2q6fB-2kikA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2kik ARTIFICIAL DIIRON
PROTEIN
(-) 		3 / 5 GLY A   9
GLY A  13
GLU A  36
 None
None
ZN  A  50 ( 2.5A)
 0.36A 4z2eA-2kikA:
undetectable
4z2eD-2kikA:
undetectable		 4z2eA-2kikA:
8.56
4z2eD-2kikA:
14.76