SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kin'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 2kin KINESIN
(Rattus
norvegicus) 		5 / 12 ALA B 268
LEU B 269
ALA B 270
THR B 326
ILE B 300
 None
 1.01A 2jjpA-2kinB:
undetectable		 2jjpA-2kinB:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2kin KINESIN
(Rattus
norvegicus) 		5 / 10 LEU B 292
ILE B 266
SER B 260
SER B 258
GLY B 263
 None
 1.43A 3ik6B-2kinB:
undetectable
3ik6E-2kinB:
undetectable		 3ik6B-2kinB:
19.77
3ik6E-2kinB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 2kin KINESIN
(Rattus
norvegicus) 		5 / 10 LEU B 292
ILE B 266
SER B 260
SER B 258
GLY B 263
 None
 1.44A 3iluB-2kinB:
undetectable
3iluE-2kinB:
undetectable		 3iluB-2kinB:
19.77
3iluE-2kinB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 2kin KINESIN
(Rattus
norvegicus) 		3 / 3 LEU B 318
LYS B 315
THR B 314
 None
 0.63A 4lj0A-2kinB:
undetectable		 4lj0A-2kinB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 2kin KINESIN
(Rattus
norvegicus) 		5 / 10 PRO B 278
ILE B 266
SER B 260
SER B 258
GLY B 263
 None
 1.43A 5weoA-2kinB:
undetectable
5weoD-2kinB:
undetectable		 5weoA-2kinB:
6.92
5weoD-2kinB:
6.92