SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kiv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2kiv ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 8 LEU A   8
GLY A 123
ILE A 122
VAL A   4
 None
 0.59A 1d4sB-2kivA:
undetectable		 1d4sB-2kivA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2kiv ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 8 LEU A  20
ILE A  55
ILE A  44
ILE A  46
 None
 0.78A 2bu8A-2kivA:
undetectable		 2bu8A-2kivA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2kiv ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 8 TYR A  16
ILE A  44
ILE A  55
ARG A  52
 None
 0.83A 2bu8A-2kivA:
undetectable		 2bu8A-2kivA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_ACTA502_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2kiv ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 4 LYS A 126
ARG A 127
GLY A 123
ASP A  40
 None
 1.14A 4ryaA-2kivA:
undetectable		 4ryaA-2kivA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2kiv ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 5 LEU A 132
PHE A  94
LEU A 113
TRP A  81
 None
 1.45A 5m10A-2kivA:
undetectable		 5m10A-2kivA:
13.41