SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kki'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P7R_A_NCTA440_1 (CYTOCHROME P450-CAM)	2kki	INTERLEUKIN-1 ALPHA (Homo sapiens)	4 / 7	PHE A 152 VAL A 90 ASP A 26 ILE A 32	None	1.00A	1p7rA-2kkiA: undetectable	1p7rA-2kkiA: 17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NC3_A_ERMA1202_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562)	2kki	INTERLEUKIN-1 ALPHA (Homo sapiens)	4 / 6	THR A 69 GLN A 88 LEU A 142 GLU A 86	None	0.95A	4nc3A-2kkiA: undetectable	4nc3A-2kkiA: 17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	2kki	INTERLEUKIN-1 ALPHA (Homo sapiens)	4 / 8	THR A 150 GLY A 145 GLY A 144 ASP A 85	None	0.60A	4qvvK-2kkiA: undetectable 4qvvL-2kkiA: undetectable	4qvvK-2kkiA: 20.98 4qvvL-2kkiA: 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	2kki	INTERLEUKIN-1 ALPHA (Homo sapiens)	4 / 8	THR A 150 GLY A 145 GLY A 144 ASP A 85	None	0.60A	4qvvY-2kkiA: undetectable 4qvvZ-2kkiA: undetectable	4qvvY-2kkiA: 20.98 4qvvZ-2kkiA: 20.98

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1P7R_A_NCTA440_1","CYTOCHROME P450-CAM","2kki","INTERLEUKIN-1 ALPHA","Homo sapiens",4,"PHE A 152;VAL A  90;ASP A  26;ILE A  32","None","1.00A","1p7rA-2kkiA:undetectable","1p7rA-2kkiA:17.60"],["4NC3_A_ERMA1202_2","CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562","2kki","INTERLEUKIN-1 ALPHA","Homo sapiens",4,"THR A  69;GLN A  88;LEU A 142;GLU A  86","None","0.95A","4nc3A-2kkiA:undetectable","4nc3A-2kkiA:17.44"],["4QVV_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","2kki","INTERLEUKIN-1 ALPHA","Homo sapiens",4,"THR A 150;GLY A 145;GLY A 144;ASP A  85","None","0.60A","4qvvK-2kkiA:undetectable;4qvvL-2kkiA:undetectable","4qvvK-2kkiA:20.98;4qvvL-2kkiA:20.98"],["4QVV_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","2kki","INTERLEUKIN-1 ALPHA","Homo sapiens",4,"THR A 150;GLY A 145;GLY A 144;ASP A  85","None","0.60A","4qvvY-2kkiA:undetectable;4qvvZ-2kkiA:undetectable","4qvvY-2kkiA:20.98;4qvvZ-2kkiA:20.98"]]