SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		4 / 4 SER A   8
LEU A  19
TYR A 140
GLY A  37
 None
 1.42A 1liiA-2kknA:
undetectable		 1liiA-2kknA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		3 / 3 THR A 156
GLU A 153
ASP A 146
 None
 0.77A 1nt2A-2kknA:
undetectable		 1nt2A-2kknA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 145
ILE A  84
MET A  86
SER A   8
PHE A   4
 None
 1.38A 1xotA-2kknA:
undetectable		 1xotA-2kknA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 145
ILE A  84
MET A  86
SER A   8
PHE A   4
 None
 1.36A 1xotB-2kknA:
undetectable		 1xotB-2kknA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		3 / 3 CYH A  87
HIS A  88
PHE A  73
 None
 1.20A 3cr4X-2kknA:
undetectable		 3cr4X-2kknA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		4 / 8 ILE A  84
HIS A  88
VAL A  58
GLY A  57
 None
 0.89A 3em0B-2kknA:
undetectable		 3em0B-2kknA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		5 / 12 PRO A 132
LEU A 112
VAL A  58
PHE A   4
LEU A 143
 None
 1.36A 3meeA-2kknA:
undetectable		 3meeA-2kknA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		4 / 8 PRO A 132
LEU A 112
VAL A  58
LEU A 143
 None
 0.89A 4pwdA-2kknA:
undetectable		 4pwdA-2kknA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A  19
VAL A  40
ASP A  38
 None
 0.57A 4y8wC-2kknA:
undetectable		 4y8wC-2kknA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		5 / 12 PRO A 132
LEU A 112
VAL A  58
PHE A   4
LEU A 143
 None
 1.34A 5cymA-2kknA:
undetectable		 5cymA-2kknA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		5 / 12 PRO A 132
LEU A 112
VAL A  58
PHE A   4
LEU A 143
 None
 1.34A 5cyqA-2kknA:
undetectable		 5cyqA-2kknA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		4 / 6 VAL A  67
HIS A  70
LEU A  71
LEU A  48
 None
 0.92A 5hrqB-2kknA:
undetectable
5hrqI-2kknA:
undetectable
5hrqJ-2kknA:
undetectable		 5hrqB-2kknA:
9.94
5hrqI-2kknA:
5.65
5hrqJ-2kknA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		3 / 3 HIS A  88
ASP A   9
HIS A  11
 None
 0.75A 5oexA-2kknA:
undetectable		 5oexA-2kknA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		3 / 3 HIS A  88
ASP A   9
HIS A  11
 None
 0.70A 5oexB-2kknA:
undetectable		 5oexB-2kknA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		3 / 3 HIS A  88
ASP A   9
HIS A  11
 None
 0.68A 5oexC-2kknA:
undetectable		 5oexC-2kknA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		3 / 3 HIS A  88
ASP A   9
HIS A  11
 None
 0.68A 5oexD-2kknA:
undetectable		 5oexD-2kknA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		5 / 9 LEU A 112
SER A   8
GLY A  37
ILE A   7
PHE A 152
 None
 1.31A 6ebpA-2kknA:
undetectable		 6ebpA-2kknA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 2kkn UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		5 / 12 PRO A 132
LEU A 112
VAL A  58
PHE A   4
LEU A 143
 None
 1.39A 6eliA-2kknA:
undetectable		 6eliA-2kknA:
17.78