SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2klo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 2klo DNA REPLICATION
FACTOR CDT1
(Mus
musculus) 		3 / 3 ALA A 123
VAL A 120
TRP A 102
 None
 0.96A 1c4dA-2kloA:
undetectable
1c4dB-2kloA:
undetectable		 1c4dA-2kloA:
9.35
1c4dB-2kloA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2klo DNA REPLICATION
FACTOR CDT1
(Mus
musculus) 		5 / 10 LEU A 125
ALA A  51
LEU A  95
LEU A  98
LEU A 116
 None
 1.46A 1pcgB-2kloA:
undetectable		 1pcgB-2kloA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2klo DNA REPLICATION
FACTOR CDT1
(Mus
musculus) 		5 / 9 GLY A 124
LEU A 122
THR A 126
LEU A 116
LEU A  98
 None
 1.18A 2npnA-2kloA:
undetectable		 2npnA-2kloA:
21.96