SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2klt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2klt SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		4 / 8 LEU A 589
PHE A 587
ARG A 574
MET A 521
 None
 0.90A 3abkA-2kltA:
undetectable
3abkJ-2kltA:
undetectable		 3abkA-2kltA:
13.58
3abkJ-2kltA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2klt SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		4 / 7 LEU A 589
PHE A 587
ARG A 574
MET A 521
 None
 0.97A 3ag2N-2kltA:
undetectable
3ag2W-2kltA:
undetectable		 3ag2N-2kltA:
13.58
3ag2W-2kltA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2klt SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		4 / 5 ILE A 645
PHE A 587
ASP A 555
GLU A 554
 None
 1.09A 3kp6A-2kltA:
undetectable
3kp6B-2kltA:
undetectable		 3kp6A-2kltA:
22.54
3kp6B-2kltA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 2klt SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 12 LEU A 560
GLU A 508
VAL A 525
THR A 572
GLY A 519
 None
 1.14A 4q15A-2kltA:
undetectable		 4q15A-2kltA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 2klt SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 12 LEU A 560
GLU A 508
VAL A 525
THR A 572
GLY A 519
 None
 1.13A 4q15B-2kltA:
undetectable		 4q15B-2kltA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2klt SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		4 / 8 THR A 541
LEU A 589
ILE A 571
LEU A 641
 None
 0.92A 5g48A-2kltA:
undetectable		 5g48A-2kltA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2klt SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 12 LEU A 560
GLU A 508
VAL A 525
THR A 572
GLY A 519
 None
 1.05A 5xipA-2kltA:
undetectable		 5xipA-2kltA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2klt SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 12 LEU A 560
GLU A 508
VAL A 525
THR A 572
GLY A 519
 None
 1.09A 5xipC-2kltA:
undetectable		 5xipC-2kltA:
15.68