SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2km6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 11 THR A  14
LEU A  85
MET A  88
LEU A  77
MET A  80
 None
 1.29A 2idkA-2km6A:
undetectable
2idkB-2km6A:
undetectable
2idkC-2km6A:
undetectable
2idkD-2km6A:
undetectable		 2idkA-2km6A:
18.25
2idkB-2km6A:
18.25
2idkC-2km6A:
18.25
2idkD-2km6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_B_C2FB1420_0
(GLYCINE
N-METHYLTRANSFERASE)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 10 LEU A  77
MET A  80
LEU A  85
MET A  88
THR A  14
 None
 1.28A 2idkA-2km6A:
undetectable
2idkB-2km6A:
undetectable
2idkC-2km6A:
undetectable
2idkD-2km6A:
undetectable		 2idkA-2km6A:
18.25
2idkB-2km6A:
18.25
2idkC-2km6A:
18.25
2idkD-2km6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 8 MET A  93
LEU A  19
LEU A  16
THR A  73
LEU A  77
 None
 1.45A 2xfhA-2km6A:
undetectable		 2xfhA-2km6A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 6 THR A  73
VAL A  74
LEU A  15
CYH A  86
 None
 1.20A 3b6rB-2km6A:
undetectable		 3b6rB-2km6A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 LEU A  77
MET A  80
LEU A  85
MET A  88
THR A  14
 None
 1.32A 3thrA-2km6A:
undetectable
3thrB-2km6A:
undetectable
3thrC-2km6A:
undetectable
3thrD-2km6A:
undetectable		 3thrA-2km6A:
18.25
3thrB-2km6A:
18.25
3thrC-2km6A:
18.25
3thrD-2km6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 ILE A  76
ALA A  72
LEU A  12
THR A  43
ILE A  59
 None
 1.12A 4ptjA-2km6A:
undetectable		 4ptjA-2km6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 ILE A  76
ALA A  72
LEU A  12
THR A  43
ILE A  59
 None
 1.15A 4qleA-2km6A:
undetectable		 4qleA-2km6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 ILE A  76
ALA A  72
LEU A  12
THR A  43
ILE A  59
 None
 1.14A 4x5fB-2km6A:
undetectable		 4x5fB-2km6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 ILE A  76
ALA A  72
LEU A  12
THR A  43
ILE A  59
 None
 1.15A 5e8qB-2km6A:
undetectable		 5e8qB-2km6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 8 LEU A  24
LEU A  19
LEU A  60
LEU A  56
 None
 0.71A 5jqbA-2km6A:
undetectable
5jqbB-2km6A:
undetectable		 5jqbA-2km6A:
16.61
5jqbB-2km6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 ILE A  76
ALA A  72
LEU A  12
THR A  43
ILE A  59
 None
 1.15A 5ujxB-2km6A:
undetectable		 5ujxB-2km6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 ILE A  76
ALA A  72
LEU A  12
THR A  43
ILE A  59
 None
 1.11A 5z6fA-2km6A:
undetectable		 5z6fA-2km6A:
20.62