SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2km8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15
(Saccharomyces
cerevisiae) 		4 / 6 VAL B  49
GLY B  50
ALA B  83
LEU B  87
 None
 0.81A 1e7bB-2km8B:
undetectable		 1e7bB-2km8B:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15
(Saccharomyces
cerevisiae) 		5 / 12 ILE B  72
LEU B  43
PHE B  74
LEU B  87
LEU B  92
 None
 1.20A 1og5B-2km8B:
undetectable		 1og5B-2km8B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15
(Saccharomyces
cerevisiae) 		5 / 11 SER B  79
SER B  80
ALA B  83
LEU B  43
ASN B  54
 None
 1.04A 2xn5A-2km8B:
undetectable		 2xn5A-2km8B:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15
(Saccharomyces
cerevisiae) 		3 / 3 TYR B  69
ARG B  95
SER B  32
 A  A   9 ( 2.9A)
A  A   8 ( 3.2A)
None
 0.66A 4dr2I-2km8B:
undetectable
4dr2J-2km8B:
3.6		 4dr2I-2km8B:
19.23
4dr2J-2km8B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15
(Saccharomyces
cerevisiae) 		3 / 3 TYR B  69
ARG B  95
SER B  32
 A  A   9 ( 2.9A)
A  A   8 ( 3.2A)
None
 0.73A 4lf7I-2km8B:
undetectable
4lf7J-2km8B:
3.2		 4lf7I-2km8B:
19.23
4lf7J-2km8B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15
(Saccharomyces
cerevisiae) 		3 / 3 TYR B  69
ARG B  95
SER B  32
 A  A   9 ( 2.9A)
A  A   8 ( 3.2A)
None
 0.73A 4lf8I-2km8B:
undetectable
4lf8J-2km8B:
3.2		 4lf8I-2km8B:
19.23
4lf8J-2km8B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15
(Saccharomyces
cerevisiae) 		4 / 8 SER B  80
ARG B  75
PRO B  51
ILE B  53
 None
 1.00A 5jhdE-2km8B:
undetectable
5jhdG-2km8B:
undetectable		 5jhdE-2km8B:
17.31
5jhdG-2km8B:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15
(Saccharomyces
cerevisiae) 		4 / 8 LEU B  92
VAL B  28
LEU B  30
ILE B  72
 None
 0.88A 6cb4A-2km8B:
undetectable		 6cb4A-2km8B:
13.16