SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kn6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		5 / 10 ALA A 180
LEU A 141
LEU A 162
LEU A 177
LEU A 136
 None
 1.14A 2xn6A-2kn6A:
undetectable
2xn6B-2kn6A:
undetectable		 2xn6A-2kn6A:
20.23
2xn6B-2kn6A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		5 / 10 ALA A 180
LEU A 141
LEU A 162
LEU A 177
LEU A 136
 None
 1.10A 2xn7A-2kn6A:
undetectable
2xn7B-2kn6A:
undetectable		 2xn7A-2kn6A:
19.65
2xn7B-2kn6A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		4 / 8 LEU A  12
MET A  81
ALA A  82
LEU A  85
 None
 0.92A 3cldB-2kn6A:
undetectable		 3cldB-2kn6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		4 / 8 GLU A 193
ASP A 191
ARG A 125
TRP A 169
 None
 1.15A 4uhxA-2kn6A:
undetectable		 4uhxA-2kn6A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		5 / 12 VAL A  57
LEU A  85
ALA A  11
LEU A   9
ALA A  88
 None
 1.22A 4x1kA-2kn6A:
undetectable
4x1kB-2kn6A:
undetectable		 4x1kA-2kn6A:
17.58
4x1kB-2kn6A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		5 / 12 VAL A  57
LEU A  56
ARG A   5
ILE A   8
LEU A  20
 None
 1.07A 4y8wA-2kn6A:
undetectable		 4y8wA-2kn6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		3 / 3 ALA A  11
ASN A  14
LEU A  15
 None
 0.52A 5i1nC-2kn6A:
undetectable		 5i1nC-2kn6A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		3 / 3 ALA A  11
ASN A  14
LEU A  15
 None
 0.24A 5i1nB-2kn6A:
undetectable		 5i1nB-2kn6A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		3 / 3 ALA A  11
ASN A  14
LEU A  15
 None
 0.40A 5i1oC-2kn6A:
undetectable		 5i1oC-2kn6A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		3 / 3 ALA A  11
ASN A  14
LEU A  15
 None
 0.30A 5i1oA-2kn6A:
undetectable		 5i1oA-2kn6A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		3 / 3 ALA A  11
ASN A  14
LEU A  15
 None
 0.35A 5i1pA-2kn6A:
undetectable		 5i1pA-2kn6A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		3 / 3 ALA A  11
ASN A  14
LEU A  15
 None
 0.37A 5i1pD-2kn6A:
undetectable		 5i1pD-2kn6A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		4 / 8 ILE A 123
LEU A 122
LEU A 188
MET A 159
 None
 0.87A 5u4sB-2kn6A:
undetectable		 5u4sB-2kn6A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens) 		3 / 3 ALA A 135
VAL A 149
TYR A 146
 None
 0.51A 5zmqH-2kn6A:
undetectable		 5zmqH-2kn6A:
24.22