SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2knh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 2knh PROTEIN CBFA2T1
(Homo
sapiens) 		4 / 7 GLU A 343
LEU A 344
VAL A 304
LEU A 333
 None
 0.89A 1hk3A-2knhA:
undetectable		 1hk3A-2knhA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2knh PROTEIN CBFA2T1
(Homo
sapiens) 		4 / 8 LEU A 333
PHE A 332
THR A 279
LEU A 278
 None
 0.90A 1v55N-2knhA:
undetectable
1v55W-2knhA:
undetectable		 1v55N-2knhA:
11.32
1v55W-2knhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2knh PROTEIN CBFA2T1
(Homo
sapiens) 		4 / 8 LEU A 333
PHE A 332
THR A 279
LEU A 278
 None
 0.90A 2einA-2knhA:
undetectable
2einJ-2knhA:
undetectable		 2einA-2knhA:
11.32
2einJ-2knhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2knh PROTEIN CBFA2T1
(Homo
sapiens) 		4 / 7 LEU A 333
PHE A 332
ARG A 276
THR A 279
 None
 0.91A 3ag2N-2knhA:
undetectable
3ag2W-2knhA:
undetectable		 3ag2N-2knhA:
11.32
3ag2W-2knhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2knh PROTEIN CBFA2T1
(Homo
sapiens) 		4 / 8 LEU A 333
PHE A 332
THR A 279
LEU A 278
 None
 0.91A 3asoN-2knhA:
undetectable
3asoW-2knhA:
undetectable		 3asoN-2knhA:
11.32
3asoW-2knhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2knh PROTEIN CBFA2T1
(Homo
sapiens) 		4 / 7 GLN A 341
LEU A 340
LEU A 333
LEU A 337
 None
 0.88A 3bgdB-2knhA:
undetectable		 3bgdB-2knhA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 2knh PROTEIN CBFA2T1
(Homo
sapiens) 		5 / 11 LEU A 337
GLY A 302
LEU A 301
PHE A 313
LEU A 333
 None
 1.15A 4wnuA-2knhA:
undetectable		 4wnuA-2knhA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 2knh PROTEIN CBFA2T1
(Homo
sapiens) 		4 / 6 LEU A 281
LEU A 299
PHE A 323
LEU A 333
 None
 0.91A 5gs4A-2knhA:
undetectable		 5gs4A-2knhA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2knh PROTEIN CBFA2T1
(Homo
sapiens) 		4 / 8 LEU A 333
PHE A 332
THR A 279
LEU A 278
 None
 0.91A 5zcpN-2knhA:
undetectable
5zcpW-2knhA:
undetectable		 5zcpN-2knhA:
11.32
5zcpW-2knhA:
20.39