SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2knq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FSL_A_NIOA145_1 (LEGHEMOGLOBIN A)	2knq	GENERAL SECRETION PATHWAY PROTEIN H (Escherichia coli)	4 / 8	ILE A 40 PHE A 20 LEU A 84 VAL A 97	None	0.91A	1fslA-2knqA: undetectable	1fslA-2knqA: 22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FSL_B_NIOB145_1 (LEGHEMOGLOBIN A)	2knq	GENERAL SECRETION PATHWAY PROTEIN H (Escherichia coli)	4 / 8	ILE A 40 PHE A 20 LEU A 84 VAL A 97	None	0.84A	1fslB-2knqA: undetectable	1fslB-2knqA: 22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F78_A_BEZA1001_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	2knq	GENERAL SECRETION PATHWAY PROTEIN H (Escherichia coli)	5 / 9	LEU A 110 LEU A 111 LEU A 124 LEU A 80 ILE A 82	None	1.23A	2f78A-2knqA: undetectable	2f78A-2knqA: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F78_B_BEZB1002_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	2knq	GENERAL SECRETION PATHWAY PROTEIN H (Escherichia coli)	5 / 9	LEU A 110 LEU A 111 LEU A 124 LEU A 80 ILE A 82	None	1.23A	2f78B-2knqA: undetectable	2f78B-2knqA: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F7A_B_BEZB1002_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	2knq	GENERAL SECRETION PATHWAY PROTEIN H (Escherichia coli)	5 / 9	LEU A 110 LEU A 111 LEU A 124 LEU A 80 ILE A 82	None	1.01A	2f7aB-2knqA: undetectable	2f7aB-2knqA: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AX7_A_SALA1336_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	2knq	GENERAL SECRETION PATHWAY PROTEIN H (Escherichia coli)	4 / 8	SER A 34 VAL A 51 LEU A 64 ALA A 27	None	1.01A	3ax7A-2knqA: undetectable	3ax7A-2knqA: 7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L4D_A_TPFA490_1 (STEROL 14-ALPHA DEMETHYLASE)	2knq	GENERAL SECRETION PATHWAY PROTEIN H (Escherichia coli)	4 / 8	ALA A 13 ALA A 17 THR A 21 LEU A 132	None	0.97A	3l4dA-2knqA: undetectable	3l4dA-2knqA: 16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMB_A_SREA603_1 (TRANSPORTER)	2knq	GENERAL SECRETION PATHWAY PROTEIN H (Escherichia coli)	5 / 9	PRO A 37 VAL A 38 ALA A 31 GLY A 53 GLY A 35	None	1.27A	4mmbA-2knqA: undetectable	4mmbA-2knqA: 13.60

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FSL_A_NIOA145_1","LEGHEMOGLOBIN A","2knq","GENERAL SECRETION PATHWAY PROTEIN H","Escherichia coli",4,"ILE A  40;PHE A  20;LEU A  84;VAL A  97","None","0.91A","1fslA-2knqA:undetectable","1fslA-2knqA:22.50"],["1FSL_B_NIOB145_1","LEGHEMOGLOBIN A","2knq","GENERAL SECRETION PATHWAY PROTEIN H","Escherichia coli",4,"ILE A  40;PHE A  20;LEU A  84;VAL A  97","None","0.84A","1fslB-2knqA:undetectable","1fslB-2knqA:22.50"],["2F78_A_BEZA1001_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","2knq","GENERAL SECRETION PATHWAY PROTEIN H","Escherichia coli",5,"LEU A 110;LEU A 111;LEU A 124;LEU A  80;ILE A  82","None","1.23A","2f78A-2knqA:undetectable","2f78A-2knqA:22.37"],["2F78_B_BEZB1002_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","2knq","GENERAL SECRETION PATHWAY PROTEIN H","Escherichia coli",5,"LEU A 110;LEU A 111;LEU A 124;LEU A  80;ILE A  82","None","1.23A","2f78B-2knqA:undetectable","2f78B-2knqA:22.37"],["2F7A_B_BEZB1002_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","2knq","GENERAL SECRETION PATHWAY PROTEIN H","Escherichia coli",5,"LEU A 110;LEU A 111;LEU A 124;LEU A  80;ILE A  82","None","1.01A","2f7aB-2knqA:undetectable","2f7aB-2knqA:22.37"],["3AX7_A_SALA1336_1","XANTHINE DEHYDROGENASE\/OXIDASE","2knq","GENERAL SECRETION PATHWAY PROTEIN H","Escherichia coli",4,"SER A  34;VAL A  51;LEU A  64;ALA A  27","None","1.01A","3ax7A-2knqA:undetectable","3ax7A-2knqA:7.28"],["3L4D_A_TPFA490_1","STEROL 14-ALPHA DEMETHYLASE","2knq","GENERAL SECRETION PATHWAY PROTEIN H","Escherichia coli",4,"ALA A  13;ALA A  17;THR A  21;LEU A 132","None","0.97A","3l4dA-2knqA:undetectable","3l4dA-2knqA:16.63"],["4MMB_A_SREA603_1","TRANSPORTER","2knq","GENERAL SECRETION PATHWAY PROTEIN H","Escherichia coli",5,"PRO A  37;VAL A  38;ALA A  31;GLY A  53;GLY A  35","None","1.27A","4mmbA-2knqA:undetectable","4mmbA-2knqA:13.60"]]