SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kny'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXD_A_ACRA733_1 (ALPHA AMYLASE)	2kny	LRP-1, LINKER, APO-E (Homo sapiens)	4 / 6	SER A 2 LEU A 26 ASP A 28 TRP A 25	None None CA A 81 (-2.5A) None	1.35A	1mxdA-2knyA: undetectable	1mxdA-2knyA: 10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IAZ_A_AINA1202_1 (LACTOTRANSFERRIN)	2kny	LRP-1, LINKER, APO-E (Homo sapiens)	3 / 3	GLU A 131 GLY A 51 THR A 50	None	0.56A	3iazA-2knyA: undetectable	3iazA-2knyA: 15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K37_B_BCZB468_1 (NEURAMINIDASE)	2kny	LRP-1, LINKER, APO-E (Homo sapiens)	3 / 3	ARG A 24 GLU A 39 TYR A 47	None CA A 81 (-2.8A) None	0.89A	3k37B-2knyA: undetectable	3k37B-2knyA: 11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V8V_B_SAMB801_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE L)	2kny	LRP-1, LINKER, APO-E (Homo sapiens)	5 / 11	GLY A 16 ASP A 35 ASP A 38 VAL A 21 LEU A 2	None None CA A 81 (-3.2A) None None	1.21A	3v8vB-2knyA: undetectable	3v8vB-2knyA: 9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A7T_A_5FWA1001_1 (SUPEROXIDE DISMUTASE [CU-ZN])	2kny	LRP-1, LINKER, APO-E (Homo sapiens)	3 / 3	ASP A 30 LYS A 31 ASP A 32	None None CA A 81 (-3.1A)	0.73A	4a7tA-2knyA: undetectable	4a7tA-2knyA: 24.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MXD_A_ACRA733_1","ALPHA AMYLASE","2kny","LRP-1, LINKER, APO-E","Homo sapiens",4,"SER A   2;LEU A  26;ASP A  28;TRP A  25","None;None; CA A  81 (-2.5A);None","1.35A","1mxdA-2knyA:undetectable","1mxdA-2knyA:10.19"],["3IAZ_A_AINA1202_1","LACTOTRANSFERRIN","2kny","LRP-1, LINKER, APO-E","Homo sapiens",3,"GLU A 131;GLY A  51;THR A  50","None","0.56A","3iazA-2knyA:undetectable","3iazA-2knyA:15.06"],["3K37_B_BCZB468_1","NEURAMINIDASE","2kny","LRP-1, LINKER, APO-E","Homo sapiens",3,"ARG A  24;GLU A  39;TYR A  47","None; CA A  81 (-2.8A);None","0.89A","3k37B-2knyA:undetectable","3k37B-2knyA:11.31"],["3V8V_B_SAMB801_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE L","2kny","LRP-1, LINKER, APO-E","Homo sapiens",5,"GLY A  16;ASP A  35;ASP A  38;VAL A  21;LEU A   2","None;None; CA A  81 (-3.2A);None;None","1.21A","3v8vB-2knyA:undetectable","3v8vB-2knyA:9.13"],["4A7T_A_5FWA1001_1","SUPEROXIDE DISMUTASE [CU-ZN]","2kny","LRP-1, LINKER, APO-E","Homo sapiens",3,"ASP A  30;LYS A  31;ASP A  32","None;None; CA A  81 (-3.1A)","0.73A","4a7tA-2knyA:undetectable","4a7tA-2knyA:24.34"]]