SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	11GS_B_EAAB211_1 (GLUTATHIONE S-TRANSFERASE)	2kom	PARTITIONING DEFECTIVE 3 HOMOLOG (Homo sapiens)	4 / 7	PHE A 473 GLY A 503 ARG A 504 GLY A 497	None	0.86A	11gsB-2komA: undetectable	11gsB-2komA: 22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7W_A_MTXA301_1 (PTERIDINE REDUCTASE)	2kom	PARTITIONING DEFECTIVE 3 HOMOLOG (Homo sapiens)	5 / 12	PRO A 487 LEU A 519 LEU A 542 LEU A 505 ASP A 509	None	1.27A	1e7wA-2komA: undetectable	1e7wA-2komA: 18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKV_A_AERA601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	2kom	PARTITIONING DEFECTIVE 3 HOMOLOG (Homo sapiens)	4 / 5	LEU A 464 ASP A 509 GLU A 513 VAL A 527	None	0.93A	4nkvA-2komA: undetectable	4nkvA-2komA: 14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DH0_A_017A101_2 (PROTEASE)	2kom	PARTITIONING DEFECTIVE 3 HOMOLOG (Homo sapiens)	3 / 3	LEU A 494 ASP A 502 ILE A 462	None	0.55A	6dh0B-2komA: undetectable	6dh0B-2komA: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	2kom	PARTITIONING DEFECTIVE 3 HOMOLOG (Homo sapiens)	5 / 12	VAL A 540 VAL A 528 LEU A 531 PHE A 473 VAL A 517	None	1.16A	6drzA-2komA: undetectable	6drzA-2komA: 13.12

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["11GS_B_EAAB211_1","GLUTATHIONE S-TRANSFERASE","2kom","PARTITIONING DEFECTIVE 3 HOMOLOG","Homo sapiens",4,"PHE A 473;GLY A 503;ARG A 504;GLY A 497","None","0.86A","11gsB-2komA:undetectable","11gsB-2komA:22.17"],["1E7W_A_MTXA301_1","PTERIDINE REDUCTASE","2kom","PARTITIONING DEFECTIVE 3 HOMOLOG","Homo sapiens",5,"PRO A 487;LEU A 519;LEU A 542;LEU A 505;ASP A 509","None","1.27A","1e7wA-2komA:undetectable","1e7wA-2komA:18.86"],["4NKV_A_AERA601_2","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","2kom","PARTITIONING DEFECTIVE 3 HOMOLOG","Homo sapiens",4,"LEU A 464;ASP A 509;GLU A 513;VAL A 527","None","0.93A","4nkvA-2komA:undetectable","4nkvA-2komA:14.35"],["6DH0_A_017A101_2","PROTEASE","2kom","PARTITIONING DEFECTIVE 3 HOMOLOG","Homo sapiens",3,"LEU A 494;ASP A 502;ILE A 462","None","0.55A","6dh0B-2komA:undetectable","6dh0B-2komA:23.81"],["6DRZ_A_H8JA1206_0","5HT2B RECEPTOR, BRIL CHIMERA","2kom","PARTITIONING DEFECTIVE 3 HOMOLOG","Homo sapiens",5,"VAL A 540;VAL A 528;LEU A 531;PHE A 473;VAL A 517","None","1.16A","6drzA-2komA:undetectable","6drzA-2komA:13.12"]]