SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kos'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PGY_A_GLYA510_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	2kos	ACYL CARRIER PROTEIN (Streptomyces coelicolor)	4 / 6	GLU A 17 ILE A 18 GLU A 45 ALA A 49	None	1.03A	3pgyA-2kosA: undetectable 3pgyB-2kosA: undetectable	3pgyA-2kosA: 13.73 3pgyB-2kosA: 13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UY8_7_TRP71002_0 (TRYPTOPHANASE)	2kos	ACYL CARRIER PROTEIN (Streptomyces coelicolor)	4 / 4	ILE A 21 ASN A 16 ILE A 14 VAL A 46	None	1.10A	4uy87-2kosA: undetectable	4uy87-2kosA: 12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JMN_A_FUAA1101_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	2kos	ACYL CARRIER PROTEIN (Streptomyces coelicolor)	4 / 5	ILE A 7 ILE A 58 HIS A 79 VAL A 56	None SXO A 101 ( 4.3A) None None	1.03A	5jmnA-2kosA: undetectable	5jmnA-2kosA: 5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KC4_A_RBFA201_2 (RIBOFLAVIN TRANSPORTER RIBU)	2kos	ACYL CARRIER PROTEIN (Streptomyces coelicolor)	3 / 3	LYS A 67 LEU A 11 ILE A 58	None SXO A 101 ( 4.7A) SXO A 101 ( 4.3A)	0.76A	5kc4A-2kosA: undetectable	5kc4A-2kosA: 20.80

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3PGY_A_GLYA510_0","SERINE HYDROXYMETHYLTRANSFERASE","2kos","ACYL CARRIER PROTEIN","Streptomyces coelicolor",4,"GLU A  17;ILE A  18;GLU A  45;ALA A  49","None","1.03A","3pgyA-2kosA:undetectable;3pgyB-2kosA:undetectable","3pgyA-2kosA:13.73;3pgyB-2kosA:13.73"],["4UY8_7_TRP71002_0","TRYPTOPHANASE","2kos","ACYL CARRIER PROTEIN","Streptomyces coelicolor",4,"ILE A  21;ASN A  16;ILE A  14;VAL A  46","None","1.10A","4uy87-2kosA:undetectable","4uy87-2kosA:12.35"],["5JMN_A_FUAA1101_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","2kos","ACYL CARRIER PROTEIN","Streptomyces coelicolor",4,"ILE A   7;ILE A  58;HIS A  79;VAL A  56","None;SXO A 101 ( 4.3A);None;None","1.03A","5jmnA-2kosA:undetectable","5jmnA-2kosA:5.97"],["5KC4_A_RBFA201_2","RIBOFLAVIN TRANSPORTER RIBU","2kos","ACYL CARRIER PROTEIN","Streptomyces coelicolor",3,"LYS A  67;LEU A  11;ILE A  58","None;SXO A 101 ( 4.7A);SXO A 101 ( 4.3A)","0.76A","5kc4A-2kosA:undetectable","5kc4A-2kosA:20.80"]]