SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 THR A 112
ASP A 109
PRO A 107
VAL A  32
 None
 1.10A 2hdnI-2kpkA:
undetectable
2hdnJ-2kpkA:
undetectable
2hdnL-2kpkA:
undetectable		 2hdnI-2kpkA:
15.32
2hdnJ-2kpkA:
17.01
2hdnL-2kpkA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL A  32
THR A 112
ASP A 109
PRO A 107
 None
 1.14A 2hdnJ-2kpkA:
undetectable
2hdnK-2kpkA:
undetectable
2hdnL-2kpkA:
undetectable		 2hdnJ-2kpkA:
17.01
2hdnK-2kpkA:
15.32
2hdnL-2kpkA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A  50
GLY A  26
GLY A  28
 None
 0.39A 3bogC-2kpkA:
undetectable		 3bogC-2kpkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  33
GLY A  34
LEU A  46
GLY A  28
LEU A  20
 None
 1.00A 4fp9A-2kpkA:
undetectable		 4fp9A-2kpkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  33
GLY A  34
LEU A  46
GLY A  28
LEU A  20
 None
 1.00A 4fp9C-2kpkA:
undetectable		 4fp9C-2kpkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  33
GLY A  34
LEU A  46
GLY A  28
LEU A  20
 None
 1.01A 4fp9D-2kpkA:
undetectable		 4fp9D-2kpkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  33
GLY A  34
LEU A  46
GLY A  28
LEU A  20
 None
 1.00A 4fp9F-2kpkA:
undetectable		 4fp9F-2kpkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  33
GLY A  34
LEU A  46
GLY A  28
LEU A  20
 None
 1.03A 4fzvA-2kpkA:
undetectable		 4fzvA-2kpkA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LYS A   1
GLU A  36
GLY A  34
GLY A  33
 None
 0.88A 5a06D-2kpkA:
undetectable		 5a06D-2kpkA:
18.71