SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 2kr5 AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE
(Aspergillus
parasiticus) 		5 / 12 LEU A  31
VAL A  20
VAL A   8
LEU A  78
LEU A  83
 None
 1.13A 1mx1E-2kr5A:
undetectable		 1mx1E-2kr5A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 2kr5 AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE
(Aspergillus
parasiticus) 		4 / 6 ILE A  26
ARG A  53
ILE A  50
PHE A  37
 None
 1.16A 2q72A-2kr5A:
undetectable		 2q72A-2kr5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2kr5 AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE
(Aspergillus
parasiticus) 		4 / 7 ILE A  26
ARG A  53
ILE A  50
PHE A  37
 None
 1.16A 2qb4A-2kr5A:
undetectable		 2qb4A-2kr5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2kr5 AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE
(Aspergillus
parasiticus) 		5 / 8 LEU A  68
SER A  67
ARG A  55
ILE A  50
PHE A  54
 None
 1.47A 3ln1A-2kr5A:
undetectable		 3ln1A-2kr5A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2kr5 AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE
(Aspergillus
parasiticus) 		5 / 7 LEU A  68
SER A  67
ARG A  55
ILE A  50
PHE A  54
 None
 1.47A 3ln1B-2kr5A:
undetectable		 3ln1B-2kr5A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2kr5 AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE
(Aspergillus
parasiticus) 		5 / 12 VAL A   6
LEU A  68
ASP A  71
GLY A  59
LEU A  58
 None
 1.07A 6b0lB-2kr5A:
undetectable		 6b0lB-2kr5A:
23.71