SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ksm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 2ksm MYCOBACTERIUM
TUBERCULOSIS
RV0899/MT0922/OMPATB
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  97
GLY A  95
VAL A 155
LEU A 153
ALA A 138
 None
 1.31A 1e3vA-2ksmA:
undetectable		 1e3vA-2ksmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ksm MYCOBACTERIUM
TUBERCULOSIS
RV0899/MT0922/OMPATB
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 104
ALA A 105
PHE A  97
ALA A 101
ILE A  84
 None
 1.17A 2aclC-2ksmA:
undetectable		 2aclC-2ksmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ksm MYCOBACTERIUM
TUBERCULOSIS
RV0899/MT0922/OMPATB
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 104
ALA A 105
PHE A  97
ALA A 101
ILE A  84
 None
 1.23A 3uvvB-2ksmA:
undetectable		 3uvvB-2ksmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2ksm MYCOBACTERIUM
TUBERCULOSIS
RV0899/MT0922/OMPATB
(Mycobacterium
tuberculosis) 		3 / 3 SER A 136
ALA A 138
VAL A 141
 None
 0.68A 4o2bC-2ksmA:
undetectable		 4o2bC-2ksmA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 2ksm MYCOBACTERIUM
TUBERCULOSIS
RV0899/MT0922/OMPATB
(Mycobacterium
tuberculosis) 		4 / 8 THR A  92
SER A  85
THR A  90
SER A  87
 None
 0.90A 5l4eA-2ksmA:
undetectable
5l4eB-2ksmA:
undetectable
5l4eC-2ksmA:
undetectable
5l4eD-2ksmA:
undetectable
5l4eE-2ksmA:
undetectable		 5l4eA-2ksmA:
19.31
5l4eB-2ksmA:
19.31
5l4eC-2ksmA:
19.31
5l4eD-2ksmA:
19.31
5l4eE-2ksmA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2ksm MYCOBACTERIUM
TUBERCULOSIS
RV0899/MT0922/OMPATB
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  95
PHE A  97
HIS A 125
VAL A 126
 None
 1.03A 6hu9S-2ksmA:
undetectable
6hu9q-2ksmA:
undetectable		 6hu9S-2ksmA:
16.94
6hu9q-2ksmA:
21.13