SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kt1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJO_B_SAMB200_1 (METHIONINE REPRESSOR)	2kt1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (Homo sapiens)	5 / 9	GLU A 24 ARG A 17 LEU A 26 ALA A 11 LEU A 31	None	1.50A	1mjoB-2kt1A: undetectable	1mjoB-2kt1A: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DZY_A_9CRA463_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	2kt1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (Homo sapiens)	5 / 12	ALA A 37 LEU A 38 ALA A 36 VAL A 75 LEU A 23	None	1.11A	3dzyA-2kt1A: undetectable	3dzyA-2kt1A: 10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMB_A_SREA603_1 (TRANSPORTER)	2kt1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (Homo sapiens)	5 / 9	ASP A 69 PRO A 51 VAL A 54 GLY A 59 GLY A 72	None	1.13A	4mmbA-2kt1A: undetectable	4mmbA-2kt1A: 10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XNX_A_41XA707_1 (TRANSPORTER)	2kt1	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (Homo sapiens)	5 / 11	PHE A 70 ASP A 69 VAL A 54 VAL A 75 GLY A 72	None	1.22A	4xnxA-2kt1A: undetectable	4xnxA-2kt1A: 10.43

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MJO_B_SAMB200_1","METHIONINE REPRESSOR","2kt1","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA","Homo sapiens",5,"GLU A  24;ARG A  17;LEU A  26;ALA A  11;LEU A  31","None","1.50A","1mjoB-2kt1A:undetectable","1mjoB-2kt1A:21.70"],["3DZY_A_9CRA463_1","RETINOIC ACID RECEPTOR RXR-ALPHA","2kt1","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA","Homo sapiens",5,"ALA A  37;LEU A  38;ALA A  36;VAL A  75;LEU A  23","None","1.11A","3dzyA-2kt1A:undetectable","3dzyA-2kt1A:10.92"],["4MMB_A_SREA603_1","TRANSPORTER","2kt1","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA","Homo sapiens",5,"ASP A  69;PRO A  51;VAL A  54;GLY A  59;GLY A  72","None","1.13A","4mmbA-2kt1A:undetectable","4mmbA-2kt1A:10.20"],["4XNX_A_41XA707_1","TRANSPORTER","2kt1","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA","Homo sapiens",5,"PHE A  70;ASP A  69;VAL A  54;VAL A  75;GLY A  72","None","1.22A","4xnxA-2kt1A:undetectable","4xnxA-2kt1A:10.43"]]