SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_D_THAD4_2 (LIVER CARBOXYLESTERASE I)	2kts	HEAT SHOCK PROTEIN HSLJ (Escherichia coli)	3 / 3	PHE A 33 LEU A 58 MET A 85	None	0.82A	1mx1D-2ktsA: undetectable	1mx1D-2ktsA: 11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E26_A_PAUA602_0 (PANTOTHENATE KINASE 2, MITOCHONDRIAL)	2kts	HEAT SHOCK PROTEIN HSLJ (Escherichia coli)	4 / 7	GLY A 49 SER A 40 GLY A 41 ALA A 64	None	0.83A	5e26A-2ktsA: undetectable 5e26B-2ktsA: undetectable	5e26A-2ktsA: 15.89 5e26B-2ktsA: 15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E26_D_PAUD601_0 (PANTOTHENATE KINASE 2, MITOCHONDRIAL)	2kts	HEAT SHOCK PROTEIN HSLJ (Escherichia coli)	4 / 8	ALA A 64 GLY A 49 SER A 40 GLY A 41	None	0.87A	5e26C-2ktsA: undetectable 5e26D-2ktsA: undetectable	5e26C-2ktsA: 15.89 5e26D-2ktsA: 15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ECT_A_SAMA1300_1 (STIE PROTEIN)	2kts	HEAT SHOCK PROTEIN HSLJ (Escherichia coli)	4 / 5	THR A 100 THR A 81 GLN A 106 ASP A 79	None	1.45A	6ectA-2ktsA: undetectable	6ectA-2ktsA: 16.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MX1_D_THAD4_2","LIVER CARBOXYLESTERASE I","2kts","HEAT SHOCK PROTEIN HSLJ","Escherichia coli",3,"PHE A  33;LEU A  58;MET A  85","None","0.82A","1mx1D-2ktsA:undetectable","1mx1D-2ktsA:11.70"],["5E26_A_PAUA602_0","PANTOTHENATE KINASE 2, MITOCHONDRIAL","2kts","HEAT SHOCK PROTEIN HSLJ","Escherichia coli",4,"GLY A  49;SER A  40;GLY A  41;ALA A  64","None","0.83A","5e26A-2ktsA:undetectable;5e26B-2ktsA:undetectable","5e26A-2ktsA:15.89;5e26B-2ktsA:15.89"],["5E26_D_PAUD601_0","PANTOTHENATE KINASE 2, MITOCHONDRIAL","2kts","HEAT SHOCK PROTEIN HSLJ","Escherichia coli",4,"ALA A  64;GLY A  49;SER A  40;GLY A  41","None","0.87A","5e26C-2ktsA:undetectable;5e26D-2ktsA:undetectable","5e26C-2ktsA:15.89;5e26D-2ktsA:15.89"],["6ECT_A_SAMA1300_1","STIE PROTEIN","2kts","HEAT SHOCK PROTEIN HSLJ","Escherichia coli",4,"THR A 100;THR A  81;GLN A 106;ASP A  79","None","1.45A","6ectA-2ktsA:undetectable","6ectA-2ktsA:16.51"]]