SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ku7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2ku7 MLL1 PHD3-CYP33 RRM
CHIMERIC PROTEIN
(Homo
sapiens) 		5 / 10 LEU A  19
PRO A  96
TYR A  24
SER A  28
GLU A  22
 None
 1.36A 1fdwA-2ku7A:
undetectable		 1fdwA-2ku7A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2ku7 MLL1 PHD3-CYP33 RRM
CHIMERIC PROTEIN
(Homo
sapiens) 		5 / 11 PRO A  96
LEU A  27
VAL A  65
TYR A  67
LEU A  30
 None
 1.27A 1lwcA-2ku7A:
undetectable		 1lwcA-2ku7A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2ku7 MLL1 PHD3-CYP33 RRM
CHIMERIC PROTEIN
(Homo
sapiens) 		4 / 8 LEU A  27
VAL A  65
TYR A  67
LEU A  30
 None
 0.92A 3v81A-2ku7A:
undetectable		 3v81A-2ku7A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ku7 MLL1 PHD3-CYP33 RRM
CHIMERIC PROTEIN
(Homo
sapiens) 		5 / 9 PRO A  96
LEU A  27
VAL A  65
TYR A  67
LEU A  30
 None
 1.26A 4puoA-2ku7A:
1.8		 4puoA-2ku7A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ku7 MLL1 PHD3-CYP33 RRM
CHIMERIC PROTEIN
(Homo
sapiens) 		5 / 8 PRO A  96
LEU A  27
VAL A  65
TYR A  67
LEU A  30
 None
 1.22A 4pwdA-2ku7A:
undetectable		 4pwdA-2ku7A:
14.82