SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kue'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2kue SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 5 PRO A 498
ILE A 497
GLY A 542
LYS A 495
 None
 1.13A 2qeuA-2kueA:
undetectable
2qeuC-2kueA:
undetectable		 2qeuA-2kueA:
21.38
2qeuC-2kueA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2kue SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 444
ILE A 468
GLY A 469
VAL A 484
GLY A 489
 None
 0.95A 3bwcB-2kueA:
undetectable		 3bwcB-2kueA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 2kue SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 533
GLY A 502
SER A 556
 None
 0.70A 4b53B-2kueA:
undetectable		 4b53B-2kueA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2kue SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 479
SER A 478
VAL A 484
ARG A 451
 None
 1.11A 4ijiH-2kueA:
undetectable		 4ijiH-2kueA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2kue SERINE/THREONINE-PRO
TEIN KINASE PKNB
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 553
SER A 521
PHE A 520
 None
 0.60A 6fgcA-2kueA:
undetectable		 6fgcA-2kueA:
17.13