SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kvk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJE_A_C2FA300_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	2kvk	ACTIN SEVERING AND DYNAMICS REGULATORY PROTEIN (Leishmania donovani)	5 / 12	GLU A 45 ASP A 18 LEU A 81 ASP A 68 SER A 47	None	1.46A	4djeA-2kvkA: undetectable	4djeA-2kvkA: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G8Z_X_TOPX301_1 (DIHYDROFOLATE REDUCTASE)	2kvk	ACTIN SEVERING AND DYNAMICS REGULATORY PROTEIN (Leishmania donovani)	5 / 10	ILE A 31 ALA A 101 SER A 108 ILE A 38 TYR A 64	None	1.23A	4g8zX-2kvkA: undetectable	4g8zX-2kvkA: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OU1_A_BEZA302_0 (RETRO-ALDOLASE, DESIGN RA114)	2kvk	ACTIN SEVERING AND DYNAMICS REGULATORY PROTEIN (Leishmania donovani)	4 / 8	TYR A 64 ILE A 31 ILE A 38 ALA A 105	None	0.91A	4ou1A-2kvkA: undetectable	4ou1A-2kvkA: 20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEP_A_VDYA201_2 (CDL2.3B)	2kvk	ACTIN SEVERING AND DYNAMICS REGULATORY PROTEIN (Leishmania donovani)	5 / 9	ILE A 116 PRO A 115 LEU A 19 ILE A 16 LEU A 124	None	1.44A	5iepA-2kvkA: undetectable	5iepA-2kvkA: 22.70

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4DJE_A_C2FA300_0","5-METHYLTETRAHYDROFOLATE CORRINOID\/IRON SULFUR PROTEIN METHYLTRANSFERASE","2kvk","ACTIN SEVERING AND DYNAMICS REGULATORY PROTEIN","Leishmania donovani",5,"GLU A  45;ASP A  18;LEU A  81;ASP A  68;SER A  47","None","1.46A","4djeA-2kvkA:undetectable","4djeA-2kvkA:22.18"],["4G8Z_X_TOPX301_1","DIHYDROFOLATE REDUCTASE","2kvk","ACTIN SEVERING AND DYNAMICS REGULATORY PROTEIN","Leishmania donovani",5,"ILE A  31;ALA A 101;SER A 108;ILE A  38;TYR A  64","None","1.23A","4g8zX-2kvkA:undetectable","4g8zX-2kvkA:21.26"],["4OU1_A_BEZA302_0","RETRO-ALDOLASE, DESIGN RA114","2kvk","ACTIN SEVERING AND DYNAMICS REGULATORY PROTEIN","Leishmania donovani",4,"TYR A  64;ILE A  31;ILE A  38;ALA A 105","None","0.91A","4ou1A-2kvkA:undetectable","4ou1A-2kvkA:20.08"],["5IEP_A_VDYA201_2","CDL2.3B","2kvk","ACTIN SEVERING AND DYNAMICS REGULATORY PROTEIN","Leishmania donovani",5,"ILE A 116;PRO A 115;LEU A  19;ILE A  16;LEU A 124","None","1.44A","5iepA-2kvkA:undetectable","5iepA-2kvkA:22.70"]]