SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kvp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 2kvp TALIN-1
(Mus
musculus) 		5 / 12 LEU A1968
ALA A1906
ALA A1903
VAL A1964
LEU A1896
 None
 1.37A 1rbpA-2kvpA:
undetectable		 1rbpA-2kvpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 2kvp TALIN-1
(Mus
musculus) 		5 / 12 LEU A1923
GLY A1894
ALA A1897
VAL A1964
VAL A1920
 None
 0.90A 2ieoB-2kvpA:
undetectable		 2ieoB-2kvpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 2kvp TALIN-1
(Mus
musculus) 		5 / 12 LEU A1923
GLY A1894
ALA A1897
VAL A1964
VAL A1920
 None
 0.94A 2nnkA-2kvpA:
undetectable		 2nnkA-2kvpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 2kvp TALIN-1
(Mus
musculus) 		4 / 6 LEU A1968
LEU A1965
ILE A1916
ARG A1919
 None
 0.86A 2rlfA-2kvpA:
undetectable
2rlfB-2kvpA:
undetectable		 2rlfA-2kvpA:
20.37
2rlfB-2kvpA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2kvp TALIN-1
(Mus
musculus) 		4 / 6 LEU A1968
LEU A1965
ILE A1916
ARG A1919
 None
 0.87A 2rlfC-2kvpA:
undetectable
2rlfD-2kvpA:
undetectable		 2rlfC-2kvpA:
20.37
2rlfD-2kvpA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2kvp TALIN-1
(Mus
musculus) 		5 / 11 LEU A1968
ALA A1906
ALA A1903
VAL A1964
LEU A1896
 None
 1.30A 3bszE-2kvpA:
undetectable		 3bszE-2kvpA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2kvp TALIN-1
(Mus
musculus) 		5 / 12 ALA A1861
LEU A1968
LEU A1965
SER A1958
ALA A1903
 None
 1.28A 3lbdA-2kvpA:
undetectable		 3lbdA-2kvpA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 2kvp TALIN-1
(Mus
musculus) 		5 / 10 LEU A1923
GLY A1894
ALA A1897
VAL A1964
VAL A1920
 None
 0.89A 3nu9B-2kvpA:
undetectable		 3nu9B-2kvpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 2kvp TALIN-1
(Mus
musculus) 		5 / 12 LEU A1923
GLY A1894
ALA A1897
VAL A1964
VAL A1920
 None
 0.88A 3ucbA-2kvpA:
undetectable		 3ucbA-2kvpA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 2kvp TALIN-1
(Mus
musculus) 		5 / 12 LEU A1923
GLY A1894
ALA A1897
VAL A1964
VAL A1920
 None
 0.87A 3ucbB-2kvpA:
undetectable		 3ucbB-2kvpA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2kvp TALIN-1
(Mus
musculus) 		4 / 7 LEU A1923
ARG A1895
VAL A1866
MET A1871
 None
 1.25A 4klrA-2kvpA:
undetectable		 4klrA-2kvpA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 2kvp TALIN-1
(Mus
musculus) 		3 / 3 GLY A1841
PRO A1842
ALA A1903
 None
 0.50A 4qn9B-2kvpA:
undetectable		 4qn9B-2kvpA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2kvp TALIN-1
(Mus
musculus) 		3 / 3 GLN A1888
ILE A1835
HIS A1925
 None
 0.68A 5z12B-2kvpA:
undetectable		 5z12B-2kvpA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 2kvp TALIN-1
(Mus
musculus) 		5 / 12 LEU A1923
GLY A1894
ALA A1897
VAL A1964
VAL A1920
 None
 0.95A 6dh0A-2kvpA:
undetectable		 6dh0A-2kvpA:
18.29